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Comment & Response |

Comparison of Methods to Diagnose Sarcoidosis

Marjolein Drent, MD, PhD1; Robert P. Baughman, MD2
[+] Author Affiliations
1Department of Toxicology, University Maastricht, Maastricht, the Netherlands
2Department of Medicine, University of Cincinnati Medical Center, Cincinnati, Ohio
JAMA. 2013;310(15):1624-1625. doi:10.1001/jama.2013.277317.
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To the Editor Dr von Bartheld and colleagues1 reported that among patients with suspected stage I/II pulmonary sarcoidosis undergoing tissue confirmation, the use of endosonographic nodal aspiration compared with bronchoscopic biopsy resulted in greater diagnostic yield.

Even though this was the focus of their study, they also reported bronchoalveolar lavage (BAL) results to assess its utility in diagnosing sarcoidosis. As also reported previously,25 the value of a BAL in diagnosing sarcoidosis, as measured by CD4/CD8 ratio analysis with a cutoff value of 3.5, was limited.

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October 16, 2013
Jouke T. Annema, MD, PhD
1Department of Pulmonology, University of Amsterdam Academic Medical Center, Amsterdam, the Netherlands
JAMA. 2013;310(15):1625-1626. doi:10.1001/jama.2013.277322.
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