Editorial |

Is There a Role for β-Blockade in Septic Shock?

Michael R. Pinsky, MD1
[+] Author Affiliations
1Department of Critical Care Medicine, University of Pittsburgh, Pittsburgh, Pennsylvania
JAMA. 2013;310(16):1677-1678. doi:10.1001/jama.2013.278478.
Text Size: A A A
Published online


Single-cell and multicell organisms have developed elaborate networks to minimize injury, repair damage, and fend off invasion by other organisms1 with the goal of maximizing the probability of surviving overwhelming stress. These networks in higher organisms were described by Walter Cannon2 as the acute stress response. The acute stress response includes centrally mediated sympathetic neural and humoral activation, increased vascular smooth muscle tone, catecholamine and cortisol release into the bloodstream, minimized pain perception, altered intercellular and intracellular signaling and intermediary metabolism, and a proinflammatory, prothrombotic intravascular state.

Sign In to Access Full Content

Don't have Access?

Register and get free email Table of Contents alerts, saved searches, PowerPoint downloads, CME quizzes, and more

Subscribe for full-text access to content from 1998 forward and a host of useful features

Activate your current subscription (AMA members and current subscribers)

Purchase Online Access to this article for 24 hours

First Page Preview

View Large
First page PDF preview




Meets CME requirements for:
Browse CME for all U.S. States
Accreditation Information
The American Medical Association is accredited by the Accreditation Council for Continuing Medical Education to provide continuing medical education for physicians. The AMA designates this journal-based CME activity for a maximum of 1 AMA PRA Category 1 CreditTM per course. Physicians should claim only the credit commensurate with the extent of their participation in the activity. Physicians who complete the CME course and score at least 80% correct on the quiz are eligible for AMA PRA Category 1 CreditTM.
Note: You must get at least of the answers correct to pass this quiz.
You have not filled in all the answers to complete this quiz
The following questions were not answered:
Sorry, you have unsuccessfully completed this CME quiz with a score of
The following questions were not answered correctly:
Commitment to Change (optional):
Indicate what change(s) you will implement in your practice, if any, based on this CME course.
Your quiz results:
The filled radio buttons indicate your responses. The preferred responses are highlighted
For CME Course: A Proposed Model for Initial Assessment and Management of Acute Heart Failure Syndromes
Indicate what changes(s) you will implement in your practice, if any, based on this CME course.
Citing articles are presented as examples only. In non-demo SCM6 implementation, integration with CrossRef’s "Cited By" API will populate this tab (http://www.crossref.org/citedby.html).


Some tools below are only available to our subscribers or users with an online account.

Sign In to Access Full Content

Related Content

Customize your page view by dragging & repositioning the boxes below.

See Also...
Articles Related By Topic
Related Topics
PubMed Articles
Hypothermia attenuates NO production in anesthetized rats with endotoxemia. Naunyn Schmiedebergs Arch Pharmacol Published online Apr 11, 2014.;