0
Comment & Response |

Assays for Cardiac Troponins—Reply

James A. de Lemos, MD1
[+] Author Affiliations
1Division of Cardiology, University of Texas Southwestern Medical Center, Dallas
JAMA. 2013;310(14):1503-1504. doi:10.1001/jama.2013.276782.
Text Size: A A A
Published online

Extract

In Reply I agree with the key distinction that Dr Ungerer and colleagues make between analytical and diagnostic sensitivity when comparing different troponin assays. The similar diagnostic sensitivity between the contemporary and highly sensitive assay for cardiac troponin I in the study by Keller et al1 can be explained by the fact that the contemporary assay had (1) sufficient analytical sensitivity and precision to characterize cardiac troponin I values at or below the 99th percentile threshold (the MI detection limit) and (2) the 99th percentile threshold had been accurately determined for both assays. Because many contemporary assays already detect troponin levels at or below the 99th percentile value, diagnostic sensitivity should not differ substantially between good contemporary assays for troponin and highly sensitive assays.

Topics

Sign In to Access Full Content

Don't have Access?

Register and get free email Table of Contents alerts, saved searches, PowerPoint downloads, CME quizzes, and more

Subscribe for full-text access to content from 1998 forward and a host of useful features

Activate your current subscription (AMA members and current subscribers)

Purchase Online Access to this article for 24 hours

First Page Preview

View Large
/>
First page PDF preview

Figures

Tables

References

October 9, 2013
Jacobus P. J. Ungerer, FRCPA; Urs Wilgen, FRCPA; Carel J. Pretorius, FRCPA
1Department of Chemical Pathology, Pathology Queensland, Queensland, Australia
2Pathology Queensland, Queensland, Australia
JAMA. 2013;310(14):1502-1503. doi:10.1001/jama.2013.276764.
CME
Meets CME requirements for:
Browse CME for all U.S. States
Accreditation Information
The American Medical Association is accredited by the Accreditation Council for Continuing Medical Education to provide continuing medical education for physicians. The AMA designates this journal-based CME activity for a maximum of 1 AMA PRA Category 1 CreditTM per course. Physicians should claim only the credit commensurate with the extent of their participation in the activity. Physicians who complete the CME course and score at least 80% correct on the quiz are eligible for AMA PRA Category 1 CreditTM.
Note: You must get at least of the answers correct to pass this quiz.
You have not filled in all the answers to complete this quiz
The following questions were not answered:
Sorry, you have unsuccessfully completed this CME quiz with a score of
The following questions were not answered correctly:
Commitment to Change (optional):
Indicate what change(s) you will implement in your practice, if any, based on this CME course.
Your quiz results:
The filled radio buttons indicate your responses. The preferred responses are highlighted
For CME Course: A Proposed Model for Initial Assessment and Management of Acute Heart Failure Syndromes
Indicate what changes(s) you will implement in your practice, if any, based on this CME course.
NOTE:
Citing articles are presented as examples only. In non-demo SCM6 implementation, integration with CrossRef’s "Cited By" API will populate this tab (http://www.crossref.org/citedby.html).

Multimedia

Some tools below are only available to our subscribers or users with an online account.

Sign In to Access Full Content

Related Content

Customize your page view by dragging & repositioning the boxes below.

See Also...
Related Topics
Jobs
brightcove.createExperiences();