Study concept and design: Messier, Mihalko, Legault, Miller, Nicklas, DeVita, Williamson, Carr, Loeser.
Acquisition of data: Messier, Legault, Nicklas, Williamson, Carr, Guermazi, Loeser.
Analysis and interpretation of data: Messier, Legault, Miller, Nicklas, DeVita, Beavers, Hunter, Lyles, Eckstein, Williamson, Carr, Guermazi, Loeser.
Drafting of the manuscript: Messier, Mihalko, Legault, Nicklas, DeVita, Hunter, Lyles, Williamson, Loeser.
Critical revision of the manuscript for important intellectual content: Messier, Mihalko, Legault, Miller, Nicklas, DeVita, Beavers, Hunter, Lyles, Eckstein, Williamson, Carr, Guermazi, Loeser.
Statistical analysis: Messier, Legault, Beavers.
Obtained funding: Messier, Mihalko, Legault, Miller, DeVita, Williamson, Carr, Loeser.
Administrative, technical, or material support: Messier, Legault, DeVita, Beavers, Hunter, Lyles, Eckstein, Williamson.
Study supervision: Messier, Mihalko, Legault, Miller, Nicklas, Lyles, Williamson, Carr, Guermazi, Loeser.
Conflict of Interest Disclosures: All authors have completed and submitted the ICMJE Form for Disclosure of Potential Conflicts of Interest. Dr Messier reported receiving grants from the US Army, giving expert testimony for Anspach Meeks Ellenberger, receiving payments for lectures from the Michigan Arthritis Collaboration and Boston University, and receiving travel expenses from the Hospital for Special Surgery Osteoarthritis Summit. Dr Legault reported receiving payment for lectures from Charité University in Berlin. Dr DeVita reported consulting with Wake Forest personnel on knee biomechanics and receiving grants from the Department of Defense and the National Institutes of Health (NIH). Dr Beavers reported receiving grants from the NIH. Dr Hunter reported serving on the board of the Osteoarthritis Research Society International; receiving grants from the National Health and Medical Research Council, Australian Research Council, and the NIH; and receiving royalties from DonJoy. Dr Lyles reported receiving a grant from the NIH. Dr Eckstein reported receiving a grant from the NIH; consulting fees from MerckSerono, Novartis, Abbott, Perceptive, Bioclinica; serving on a speakers’ bureau for Synthes and Medtronic; owning stock from Chondrometrics; and receiving travel expenses from MerckSerono. Dr Guermazi reported serving as a consultant for Genzyme, Astra-Zeneca, Novartis, MerckSerono, TissueGene, and sanofi-aventis and owning stock from Boston Imaging Core Lab. No other disclosures were reported.
Funding/Support: Support for this study was provided by grants from the National Institutes of Health—R01 AR052528-01 from the National Institute of Arthritis and Musculoskeletal and Skin Diseases, P30 AG21332 from the National Institute on Aging, M01-RR00211 from the National Center for Research Resources—and by General Nutrition Centers.
Role of the Sponsor: The sponsors had no role in the design and conduct of the study; collection, analysis, and interpretation of data; preparation, review, or approval of the manuscript; and decision to submit the manuscript for publication.
Additional Contributions: We thank the IDEA research staff and the IDEA participants for their important contributions. The participants did not receive compensation for their contributions, and the staff were not compensated besides their salaries.