Study concept and design: Berry, Samelson, Kiel.
Acquisition of data: McLean, Broe, Kiel.
Analysis and interpretation of data: All authors.
Drafting of the manuscript: Berry, Samelson.
Critical revision of the manuscript for important intellectual content: Samelson, Pencina, McLean, Cupples, Broe, Kiel.
Statistical analysis: Berry, Samelson, Pencina, Cupples.
Obtained funding: Kiel.
Administrative, technical, or material support: Broe, Kiel.
Study supervision: Kiel.
Conflict of Interest Disclosures: All authors have completed and submitted the ICMJE Form for Disclosure of Potential Conflicts of Interest. Dr Berry reports receiving royalties for her author contributions to UpToDate. Dr Kiel reports receiving grants from Amgen, Eli Lilly, Hologic, Merck Sharp & Dohme, and Roche; receiving consulting fees for serving on scientific advisory boards from Amgen, Ammonett Pharma, Eli Lilly, Merck Sharp & Dohme, and Novartis; and receiving royalties for his author contributions to UpToDate and Springer. No other disclosures were reported.
Funding/Support: This work was funded in part through grants R01-AR/AG 41398 and NIA K23 AG033204 from the National Institutes of Health, N01-HC-25195 from the National Heart, Lung, and Blood Institute's Framingham Heart Study, and contributions from the Friends of Hebrew SeniorLife.
Role of the Sponsor: The National Institutes of Health, National Heart, Lung, and Blood Institute, and Friends of Hebrew SeniorLife had no role in the design and conduct of the study; collection, management, analysis, and interpretation of the data; preparation, review, or approval of the manuscript; and decision to submit the manuscript for publication.