Patients with diabetes and physicians are aware of the distress and on rare occasions mortality caused by severe hypoglycemia, in particular by nocturnal hypoglycemia. Up to 75% of severe hypoglycemia episodes in children occur at night,1 and concern about hypoglycemia is a major barrier to achieving target glycemic levels, often leading to maladaptive behaviors, such as underdosing insulin or taking extra carbohydrates, that increase blood glucose levels, again most pronounced at night.2
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