Study concept and design: Mathurin, Louvet, Duhamel.
Acquisition of data: Mathurin, Louvet, Nahon, Carbonell, Boursier, Anty, Diaz, Thabut, Moirand, Lebrec, Moreno, Talbodec, Paupard, Naveau, Silvain, Pageaux, Sobesky, Canva-Delcambre, Dharancy, Dao.
Analysis and interpretation of data: Mathurin, Louvet, Duhamel, Salleron.
Drafting of the manuscript: Mathurin, Louvet, Duhamel, Salleron.
Critical revision of the manuscript for important intellectual content: Mathurin, Louvet, Duhamel, Nahon, Carbonell, Boursier, Anty, Diaz, Thabut, Moirand, Lebrec, Moreno, Talbodec, Paupard, Naveau, Silvain, Pageaux, Sobesky, Canva-Delcambre, Dharancy, Salleron, Dao.
Statistical analysis: Mathurin, Louvet, Duhamel, Salleron.
Obtained funding: Mathurin.
Administrative, technical, or material support: Mathurin, Louvet, Duhamel, Salleron.
Study supervision: Mathurin, Louvet, Duhamel, Salleron.
Conflict of Interest Disclosures: All authors have completed and submitted the ICMJE Form for Disclosure of Potential Conflicts of Interest and none were reported.
Funding/Support: This work was supported by a Hospital-Based Clinical Research Program, a grant from the French Minister of Health. Pentoxifylline and its matching placebo were both supplied by Sanofi-Aventis Pharmaceuticals.
Role of the Sponsor: The funding sponsors had no role in the design and conduct of the study; collection, management, analysis, and interpretation of the data; and preparation, review, or approval of the manuscript.
Study Investigators and Centers: A.-B. Marks-Brunel, MD (Centre Hospitalier de Valenciennes, France); J.-P. Bronowicki, MD (CHU de Nancy, France); C. Duvoux, MD (Hôpital Henri Mondor, Créteil, France); T. Davion, MD (Centre Hospitalier de Lens, France); F. Guillemot, MD (Centre Hospitalier de Roubaix, France); P. Sogni, MD (Hôpital Cochin, Paris, France); J.-F. Cadranel, MD (Centre Hospitalier de Creil, France).
Previous Presentations: Presented as an abstract in the following meetings: American Association for the Study of Liver Diseases; November 6, 2011; San Francisco, California; European Association for the Study of the Liver; April 21, 2012; Barcelona, Spain; and Journées Francophones d’Hépato-gastroentérologie et d’Oncologie Digestive; March 15, 2012; Paris, France.
Additional Contributions: We thank Aurélie Gozdziaszek (clinical research assistant, Direction à la Recherche Clinique et à l’Innovation, CHRU de Lille, France) for her contribution to this study. Ms Gozdziaszek did not receive any compensation.