Study concept and design: Sankilampi, Saari, Dunkel.
Acquisition of data: Sankilampi, Saari, Dunkel.
Analysis and interpretation of data: Sankilampi, Saari, Laine, Dunkel.
Drafting of the manuscript: Sankilampi, Saari, Laine, Miettinen, Dunkel.
Critical revision of the manuscript for important intellectual content: Sankilampi, Saari, Dunkel.
Statistical analysis: Sankilampi.
Obtained funding: Sankilampi, Dunkel.
Administrative, technical, or material support: Sankilampi, Dunkel.
Study supervision: Dunkel.
Conflict of Interest Disclosures: The authors have completed and submitted the ICMJE Form for Disclosure of Potential Conflicts of Interest. Dr Sankilampi reported receiving travel support from Merck Serono. No other disclosures were reported.
Funding/Support: This study was supported by the Finnish Funding Agency for Technology and Innovation and Kuopio University Hospital.
Role of the Sponsor: The Finnish Funding Agency for Technology and Innovation and Kuopio University Hospital had no role in the design and conduct of the study; collection, management, analysis, and interpretation of the data; preparation, review, or approval of the manuscript; and decision to submit the manuscript for publication.
Additional Contributions: We thank Laura Valpio, MD (University of Eastern Finland, Kuopio), for her help with data acquisition. Dr Valpio did not receive compensation for her contribution.