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Comment & Response |

Genetic Variants Associated With Susceptibility to Helicobacter pylori—Reply

Julia Mayerle, MD1; Ernst J. Kuipers, MD, PhD2; Markus M. Lerch, MD, FRCP1
[+] Author Affiliations
1Department of Medicine, University Medicine Greifswald, Greifswald, Germany
2Department of Gastroenterology and Hepatology, Erasmus University Medical Center, Rotterdam, the Netherlands
JAMA. 2013;310(9):976-977. doi:10.1001/jama.2013.194772.
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In Reply The gram-negative pathogen H pylori is specifically adapted to colonize the mucus layer of the human gastric mucosa. It therefore differs from other gram-negative bacteria in several respects. First, despite the induction of a strong local immune response in the gastric mucosa of colonized individuals, the bacterium establishes chronic infection lasting up to several decades. Second, it persists strictly as an extracellular pathogen. Third, due to the different lipid A acetylation of its lipopolysaccharide, it induces 500- to 1000-fold lower endotoxic activity compared with bacteria such as Salmonella typhimurium or Escherichia coli. Fourth, even in strongly immunosuppressed patients, H pylori never causes septicemia. Therefore, the immune response to infection by H pylori maintains a balance between host and pathogen as well as the innate and the adaptive immune systems.

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September 4, 2013
Mark M. Wurfel, MD, PhD; Thomas R. Hawn, MD, PhD
1Division of Pulmonary and Critical Care Medicine, Harborview Medical Center, University of Washington, Seattle
2Division of Allergy and Infectious Diseases, University of Washington, Seattle
JAMA. 2013;310(9):976. doi:10.1001/jama.2013.194762.
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