We're unable to sign you in at this time. Please try again in a few minutes.
We were able to sign you in, but your subscription(s) could not be found. Please try again in a few minutes.
There may be a problem with your account. Please contact the AMA Service Center to resolve this issue.
Contact the AMA Service Center:
Telephone: 1 (800) 262-2350 or 1 (312) 670-7827  *   Email: subscriptions@jamanetwork.com
Error Message ......
Comment & Response |

Genetic Variants Associated With Susceptibility to Helicobacter pylori

Mark M. Wurfel, MD, PhD1; Thomas R. Hawn, MD, PhD2
[+] Author Affiliations
1Division of Pulmonary and Critical Care Medicine, Harborview Medical Center, University of Washington, Seattle
2Division of Allergy and Infectious Diseases, University of Washington, Seattle
JAMA. 2013;310(9):976. doi:10.1001/jama.2013.194762.
Text Size: A A A
Published online


To the Editor The study by Dr Mayerle and collegues1 found a strong association between variants at the toll-like receptor 10, 1, and 6 (TLR10/1/6) locus on chromosome 4 and Helicobacter pylori serologic status, which contributes to the understanding of host susceptibility to a common infectious disease. During the process of evaluating the functional significance of their finding, the authors presented results that indicate that a single-nucleotide polymorphism within this locus (rs10004195), which was identified as having the strongest association with H pylori seroprevalence, may be an expression quantitative trait locus causing reduced expression of TLR1. They suggested that decreased TLR1 messenger RNA expression or defective protein function, or both, might be responsible for the observed association with protection from the acquisition of H pylori seropositivity.


Sign in

Purchase Options

• Buy this article
• Subscribe to the journal
• Rent this article ?

First Page Preview

View Large
First page PDF preview




September 4, 2013
Julia Mayerle, MD; Ernst J. Kuipers, MD, PhD; Markus M. Lerch, MD, FRCP
1Department of Medicine, University Medicine Greifswald, Greifswald, Germany
2Department of Gastroenterology and Hepatology, Erasmus University Medical Center, Rotterdam, the Netherlands
JAMA. 2013;310(9):976-977. doi:10.1001/jama.2013.194772.
Also Meets CME requirements for:
Browse CME for all U.S. States
Accreditation Information
The American Medical Association is accredited by the Accreditation Council for Continuing Medical Education to provide continuing medical education for physicians. The AMA designates this journal-based CME activity for a maximum of 1 AMA PRA Category 1 CreditTM per course. Physicians should claim only the credit commensurate with the extent of their participation in the activity. Physicians who complete the CME course and score at least 80% correct on the quiz are eligible for AMA PRA Category 1 CreditTM.
Note: You must get at least of the answers correct to pass this quiz.
Please click the checkbox indicating that you have read the full article in order to submit your answers.
Your answers have been saved for later.
You have not filled in all the answers to complete this quiz
The following questions were not answered:
Sorry, you have unsuccessfully completed this CME quiz with a score of
The following questions were not answered correctly:
Commitment to Change (optional):
Indicate what change(s) you will implement in your practice, if any, based on this CME course.
Your quiz results:
The filled radio buttons indicate your responses. The preferred responses are highlighted
For CME Course: A Proposed Model for Initial Assessment and Management of Acute Heart Failure Syndromes
Indicate what changes(s) you will implement in your practice, if any, based on this CME course.


Some tools below are only available to our subscribers or users with an online account.

0 Citations

Sign in

Purchase Options

• Buy this article
• Subscribe to the journal
• Rent this article ?

Related Content

Customize your page view by dragging & repositioning the boxes below.

See Also...