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JAMA. 2013;310(9):873. doi:10.1001/jama.2013.5286.
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In a randomized trial of 2004 patients with or at risk of cardiovascular disease (CVD), Thom and colleagues found that compared with usual care, a fixed-dose combination medication containing aspirin, a statin, and 2 antihypertensive agents improved medication adherence, systolic blood pressure, and low-density lipoprotein cholesterol levels. In an Editorial, Gaziano discusses In an Editorial, Gaziano discusses challenges in the use of a combination “polypill” to reduce CVD risk.

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Spijkerman and colleagues randomly assigned 400 infants to receive the 13-valent pneumococcal conjugate vaccine (PCV) according to 1 of 4 different immunization schedules and found no difference in antibody levels for most serotypes at age 12 months. In an Editorial, O’Brien discusses optimal use of the PCV vaccine.

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There has been concern that provision of iron to children with iron deficiency in malaria-endemic areas may increase the malaria risk. In a cluster randomized trial involving 1958 rural Ghanaian children, Zlotkin and colleagues found that daily use of a micronutrient powder with iron did not increase the incidence of malaria. In an Editorial, Prentice and colleagues discuss iron fortification and malaria risk in children.

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Xu and colleagues analyzed data from a 2010 national sample of 98 658 Chinese adults and report estimated prevalences of diabetes and prediabetes of 11.6% and 50.1%, respectively. In an Editorial, Chan discusses control of preventable noncommunicable diseases in China.

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In an analysis of baseline data from 142 042 participants in the multinational Prospective Urban Rural Epidemiology Study Chow and collegues found 40.8% had hypertension. Among those diagnosed 46.% were aware of their diagnosis, 40.6% were receiving treatment, and blood pressure was controlled in 32% of threated individuals.

CLINICAL REVIEW & EDUCATION

In this From the JAMA Network article, Darmstadt and Munar discuss behavioral change and community mobilization to reduce neonatal mortality in high-poverty areas.

An infant born at 36 weeks’ gestation by cesarean deliver developed a widespread vesicular rash shortly after birth. The mother denied a history of sexually transmitted infections, cold sores, or genital lesions. What would you do next.

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