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Editorial |

Renin-Angiotensin System Inhibition and Secondary Cardiovascular Prevention

Jean-Claude Tardif, MD1,2; Jean Grégoire, MD1,2
[+] Author Affiliations
1Montreal Heart Institute, Montreal, Quebec, Canada
2Department of Medicine, Université de Montréal, Montreal, Quebec, Canada
JAMA. 2013;310(11):1130-1131. doi:10.1001/jama.2013.277170.
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Cardiovascular diseases remain the leading cause of mortality in the world as recently confirmed by the World Health Organization, and atherosclerosis is the main underlying origin. Atherosclerosis-related diseases are also responsible for considerable morbidity in the United States and around the world1 and for health care costs related to hospitalizations for myocardial infarction, heart failure, and stroke. Although nonpharmacological strategies including a heart-healthy diet, physical activity, and smoking cessation should always be recommended, most patients with or at high risk of coronary artery disease should receive several medications including a statin, at least 1 antiplatelet agent, and a renin-angiotensin system inhibitor (angiotensin-converting enzyme [ACE] inhibitor or, if not well tolerated, an angiotensin receptor antagonist).2

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