0
We're unable to sign you in at this time. Please try again in a few minutes.
Retry
We were able to sign you in, but your subscription(s) could not be found. Please try again in a few minutes.
Retry
There may be a problem with your account. Please contact the AMA Service Center to resolve this issue.
Contact the AMA Service Center:
Telephone: 1 (800) 262-2350 or 1 (312) 670-7827  *   Email: subscriptions@jamanetwork.com
Error Message ......
Medical News and Perspectives |

Few Studies Reporting Results at US Government Clinical Trials Site

Bridget M. Kuehn
JAMA. 2012;307(7):651-653. doi:10.1001/jama.2012.127.
Text Size: A A A
Published online

Extract

Fewer than one-quarter of the clinical trials registered at ClinicalTrials.gov (http://clinicaltrials.gov), a federal database set up to provide public information about clinical trials, have had their results posted in the database within a year of publication, 2 recent analyses have found.

The findings may suggest the need to boost awareness among researchers about the requirement to report and the value of reporting results in the database, or may require enforcement efforts by regulators or others with authority over clinical trial investigators. Federal agencies and academic institutions pushed for the creation of the database to promote greater public access to clinical trial data and to prevent the scientific literature from being skewed by selective reporting of positive results. Officials at the National Library of Medicine, which administers the database, and the US Food and Drug Administration (FDA), which is charged with enforcing participation in the database by some trials, said they are working through nuances in the law to clarify which trials are subject to the rules and have launched some efforts to boost participation.

Figures in this Article

Sign in

Create a free personal account to sign up for alerts, share articles, and more.

Purchase Options

• Buy this article
• Subscribe to the journal

First Page Preview

View Large
First page PDF preview

Figures

Place holder to copy figure label and caption

Graphic Jump LocationImage not available.

Clinical trials sponsored by industry were 3 times more likely to report their results in ClinicalTrials.gov than trials funded by the National Institutes of Health.

Tables

References

CME
Also Meets CME requirements for:
Browse CME for all U.S. States
Accreditation Information
The American Medical Association is accredited by the Accreditation Council for Continuing Medical Education to provide continuing medical education for physicians. The AMA designates this journal-based CME activity for a maximum of 1 AMA PRA Category 1 CreditTM per course. Physicians should claim only the credit commensurate with the extent of their participation in the activity. Physicians who complete the CME course and score at least 80% correct on the quiz are eligible for AMA PRA Category 1 CreditTM.
Note: You must get at least of the answers correct to pass this quiz.
Please click the checkbox indicating that you have read the full article in order to submit your answers.
Your answers have been saved for later.
You have not filled in all the answers to complete this quiz
The following questions were not answered:
Sorry, you have unsuccessfully completed this CME quiz with a score of
The following questions were not answered correctly:
Commitment to Change (optional):
Indicate what change(s) you will implement in your practice, if any, based on this CME course.
Your quiz results:
The filled radio buttons indicate your responses. The preferred responses are highlighted
For CME Course: A Proposed Model for Initial Assessment and Management of Acute Heart Failure Syndromes
Indicate what changes(s) you will implement in your practice, if any, based on this CME course.

Multimedia

Some tools below are only available to our subscribers or users with an online account.

Web of Science® Times Cited: 3

Sign in

Create a free personal account to sign up for alerts, share articles, and more.

Purchase Options

• Buy this article
• Subscribe to the journal

Related Content

Customize your page view by dragging & repositioning the boxes below.

Articles Related By Topic
Related Collections
PubMed Articles
Drug-safety pilot makes the grade. Nature 2014;513(7519):472.
Jobs
JAMAevidence.com

Users' Guides to the Medical Literature
Chapter 11.3. Dealing With Misleading Presentations of Clinical Trial Results

Users' Guides to the Medical Literature
Introduction

brightcove.createExperiences();