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Vitamin D Supplementation for Cardiovascular Disease Prevention

James H. O[rsquo]Keefe, MD; Carl J. Lavie, MD; Michael F. Holick, PhD, MD
JAMA. 2011;306(14):1546-1548. doi:10.1001/jama.2011.1465.
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To the Editor: We take issue with Drs Shapses and Manson1 in their defense of the Institute of Medicine (IOM) recommendations that the daily allowance of vitamin D be 600 IU per day for individuals aged 1 to 70 years and 800 IU per day for those older than 70 years. A recent study using the National Health and Nutrition Examination Survey 2005-2006 analyzed vitamin D levels in 4495 adults and found vitamin D deficiency, defined as a serum 25-hydroxyvitamin D level 20 ng/mL or less, in 42% of the overall population, 82% of black individuals, and 69% of Hispanic individuals.2


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