Study concept and design: Parkes, Maricar, Lunt, Felson.
Acquisition of data: Parkes, Maricar, Jones, Segal, Takahashi-Narita.
Analysis and interpretation of data: Parkes, Lunt, LaValley, Jones, Felson.
Drafting of the manuscript: Parkes, Maricar, Jones, Felson.
Critical revision of the manuscript for important intellectual content: Parkes, Maricar, Lunt, LaValley, Jones, Segal, Takahashi-Narita, Felson.
Statistical analysis: Parkes, Lunt, LaValley.
Obtained funding: Felson.
Administrative, technical, or material support: Maricar, Jones, Segal, Takahashi-Narita, Felson.
Study supervision: Lunt, Felson.
Conflict of Interest Disclosures: The authors have completed and submitted the ICMJE Form for Disclosure of Potential Conflicts of Interest. Ms Maricar reported receiving a National Institute for Health Research clinical doctoral fellowship. Dr Lunt reported receiving institutional salary support from Arthritis Research UK. Dr LaValley reported serving as a consultant for Sunovian Pharmaceuticals; and serving as associate editor for Arthritis Care & Research. Dr Segal reported serving as a continuing medical education (CME) activity editor and has received payment for CME case presentation from Vindico Medical Education; and has received grants from the Arthritis Foundation, the National Institute on Aging, and the Foundation for Physical Medicine & Rehabilitation. Dr Felson reported receiving an institutional grant from Arthritis Research UK; and serving as a consultant for Knee Creations Ltd. No other author reported disclosures.
Funding/Support: This review was funded by special strategic award grant 18676 from Arthritis Research UK. Drs LaValley and Felson are supported by grant AR47785 from the National Institute for Health and Clinical Excellence.
Role of the Sponsor: Arthritis Research UK and the National Institute for Health and Clinical Excellence had no role in the design and conduct of the study; collection, management, analysis, and interpretation of the data; preparation, review, or approval of the manuscript; and decision to submit the manuscript for publication.
Additional Contributions: We gratefully acknowledge the Research into Osteoarthritis in Manchester (ROAM) research team and Arthritis Research UK.