Study concept and design: Suri, Vanoverschelde, Grigioni, Avierinos, Russo, Enriquez-Sarano.
Acquisition of data: Suri, Vanoverschelde, Grigioni, Tribouilloy, Avierinos, Barbieri, Pasquet, Russo, Enriquez-Sarano.
Analysis and interpretation of data: Suri, Vanoverschelde, Grigioni, Schaff, Tribouilloy, Avierinos, Huebner, Rusinaru, Russo, Michelena, Enriquez-Sarano.
Drafting of the manuscript: Suri, Grigioni, Avierinos, Huebner, Enriquez-Sarano.
Critical revision of the manuscript for important intellectual content: All authors.
Statistical analysis: Suri, Huebner, Rusinaru, Enriquez-Sarano.
Obtained funding: Enriquez-Sarano.
Administrative, technical, or material support: Suri, Barbieri, Enriquez-Sarano.
Study supervision: Suri, Grigioni, Schaff, Tribouilloy, Avierinos, Barbieri, Pasquet, Russo, Michelena, Enriquez-Sarano.
Drs Enriquez-Sarano and Suri contributed equally to this work.
Conflict of Interest Disclosures: All authors have completed and submitted the ICMJE Form for Disclosure of Potential Conflicts of Interest. Dr Suri reports receiving grant funding from Edwards Lifesciences, Sorin Group, and St Jude Medical and support for travel and accommodations from Sorin Group and serving on the eligibility committee for the Abbot COAPT trial. Dr Grigioni reports receiving payment for lectures from Edwards Lifesciences. Dr Enriquez-Sarano reports serving as a board member for Valtech and receiving grant funding from Abbott Vascular.
MIDA Investigators: Christophe de Meester, Patrick Montand, Fabien Chenot, Bernhard Vancrayenest, and Gebrine El-Khoury (Brussels, Belgium); Elena Bararesi, Marinella Ferlito, Claudio Rapezzi, Angelo Branzi, Carlo Savini, and Roberto Di Bartolomeo (Bologna, Italy); Roberta Lugli, Francesca Mantovani, Chiara Manicardi, Francesca Bursi, and Maria Garzia (Modena, Italy); Catherine Szymansky, Gilles Touati, Thierry Caus, Jean Paul Remadi, Franck Levy, and Faouzi Trojette (Amiens, France); Jean-Francois Avierinos (Marseille, France); and Douglas Mahoney (Rochester, Minnesota).
Additional Contributions: We thank Zhuo Li, MSc, for expert statistical analysis, Diane Wilke, RN, for expert data abstraction, and Doug Mahoney, MSc (Mayo Clinic), for expert statistical analysis including population matching. They received a salary from their institution.