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Comment & Response |

Efficacy of Sublingual Immunotherapy—Reply

Sandra Y. Lin, MD1; Catalina Suarez-Cuervo, MD2; Jodi Segal, MD, MPH2
[+] Author Affiliations
1Department of Otolaryngology-Head and Neck Surgery, Johns Hopkins School of Medicine, Baltimore, Maryland
2Department of Medicine, Johns Hopkins School of Medicine, Baltimore, Maryland
JAMA. 2013;310(6):644-645. doi:10.1001/jama.2013.7652.
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In Reply We agree with Dr Frati and colleagues regarding the need for higher dosing with sublingual immunotherapy than subcutaneous immunotherapy. Although there are anecdotal reports of clinical use of sublingual immunotherapy in the United States, to our knowledge, there have been no published surveys of the dosing used by these physicians.

Frati and colleagues are correct that we did not report the ratio of sublingual to subcutaneous immunotherapy in our review, which is a useful comparator. However, this same information can be derived by using the micrograms per month of major allergen used in each study, which was included when available for each article in the supplementary materials.


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August 14, 2013
Heleen Moed, PhD; Esther Röder, MD, PhD; Patrick Bindels, MD, PhD
1Department of General Practice, Erasmus Medical Center, Rotterdam, the Netherlands
2Department of Allergy, Erasmus Medical Center, Rotterdam, the Netherlands
JAMA. 2013;310(6):644. doi:10.1001/jama.2013.7643.
August 14, 2013
Franco Frati, MD; Cristoforo Incorvaia, MD; Giovanni Passalacqua, MD
1Department of Medical and Surgical Specialty and Public Health, University of Perugia, Perugia, Italy
2Allergy and Pulmonary Rehabilitation Unit, ICP Hospital, Milan, Italy
3Allergy and Respiratory Diseases, University of Genoa, Genoa, Italy
JAMA. 2013;310(6):643-644. doi:10.1001/jama.2013.7646.
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