0
We're unable to sign you in at this time. Please try again in a few minutes.
Retry
We were able to sign you in, but your subscription(s) could not be found. Please try again in a few minutes.
Retry
There may be a problem with your account. Please contact the AMA Service Center to resolve this issue.
Contact the AMA Service Center:
Telephone: 1 (800) 262-2350 or 1 (312) 670-7827  *   Email: subscriptions@jamanetwork.com
Error Message ......
Comment and Response |

BRAF V600E Mutation and Papillary Thyroid Cancer—In Reply

Mingzhao Xing, MD, PhD1
[+] Author Affiliations
1Division of Endocrinology and Metabolism, Johns Hopkins University School of Medicine, Baltimore, Maryland
JAMA. 2013;310(5):534-535. doi:10.1001/jama.2013.8598.
Text Size: A A A
Published online

Extract

In Reply I disagree with Dr Ciarrocchi and colleagues that BRAF V600E has no role in the aggressiveness of PTC because of its dependence on tumor behaviors, including local and distant metastases and invasion. It is clear that PTC would not cause patient death without aggressive tumor behaviors.

Our study demonstrated a strong synergism between BRAF V600E and aggressive clinicopathological behaviors, as reflected by the strong synergy indices and the fact that the association of mortality with BRAF V600E or clinicopathological behavior alone was only moderate but increased when the 2 were considered jointly. Thus, BRAF V600E does have a significant association with mortality, which likely occurs through promoting aggressive tumor behaviors and would be misleadingly lost using conventional multivariable models. Further efforts are needed to define how to specifically use the prognostic value of BRAF V600E clinically.

Topics

Sign in

Create a free personal account to sign up for alerts, share articles, and more.

Purchase Options

• Buy this article
• Subscribe to the journal

First Page Preview

View Large
First page PDF preview

Figures

Tables

References

August 7, 2013
Alessia Ciarrocchi, PhD; Silvio Cavuto, MSc; Simonetta Piana, MD
1Laboratory of Molecular Biology, Arcispedale S Maria Nuova-IRCCS, Reggio Emilia, Italy
2Scientific Directorate, Arcispedale S Maria Nuova-IRCCS, Reggio Emilia, Italy
3Pathology Unit, Arcispedale S Maria Nuova-IRCCS, Reggio Emilia, Italy
JAMA. 2013;310(5):534. doi:10.1001/jama.2013.8589.
August 7, 2013
Mingzhao Xing, MD, PhD
1Division of Endocrinology and Metabolism, Johns Hopkins University School of Medicine, Baltimore, Maryland
JAMA. 2013;310(5):535. doi:10.1001/jama.2013.8592.
CME
Meets CME requirements for:
Browse CME for all U.S. States
Accreditation Information
The American Medical Association is accredited by the Accreditation Council for Continuing Medical Education to provide continuing medical education for physicians. The AMA designates this journal-based CME activity for a maximum of 1 AMA PRA Category 1 CreditTM per course. Physicians should claim only the credit commensurate with the extent of their participation in the activity. Physicians who complete the CME course and score at least 80% correct on the quiz are eligible for AMA PRA Category 1 CreditTM.
Note: You must get at least of the answers correct to pass this quiz.
You have not filled in all the answers to complete this quiz
The following questions were not answered:
Sorry, you have unsuccessfully completed this CME quiz with a score of
The following questions were not answered correctly:
Commitment to Change (optional):
Indicate what change(s) you will implement in your practice, if any, based on this CME course.
Your quiz results:
The filled radio buttons indicate your responses. The preferred responses are highlighted
For CME Course: A Proposed Model for Initial Assessment and Management of Acute Heart Failure Syndromes
Indicate what changes(s) you will implement in your practice, if any, based on this CME course.

Multimedia

Some tools below are only available to our subscribers or users with an online account.

Sign in

Create a free personal account to sign up for alerts, share articles, and more.

Purchase Options

• Buy this article
• Subscribe to the journal

Related Content

Customize your page view by dragging & repositioning the boxes below.

See Also...
Related Collections
Jobs
brightcove.createExperiences();