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Comment and Response |

Chelation Therapy and Cardiovascular Outcomes—In Reply

Gervasio A. Lamas, MD1; Daniel Mark, MD, MPH2; Kerry L. Lee, PhD2
[+] Author Affiliations
1Division of Cardiology, Columbia University at Mount Sinai Medical Center, Miami Beach, Florida
2Duke Clinical Research Institute, Durham, North Carolina
JAMA. 2013;310(4):431-432. doi:10.1001/jama.2013.7954.
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In Reply Dr Bittl references evidence that associates cadmium levels with atherosclerosis and points out that EDTA is an effective chelator for many xenobiotic heavy metals. Heavy metals promote oxidant stress and, as such, may be causative in atherosclerosis.1 The heavy metal hypothesis, as mentioned in the Discussion section of our article, is a possible explanation for the results of TACT.


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July 24, 2013
Bruce Kleinman, MD
1Department of Anesthesiology, Edward Hines Jr VA Hospital, Hines, Illinois
JAMA. 2013;310(4):431. doi:10.1001/jama.2013.7930.
July 24, 2013
John A. Bittl, MD
1Munroe Regional Medical Center, Ocala, Florida
JAMA. 2013;310(4):430-431. doi:10.1001/jama.2013.7933.
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