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Comment and Response |

Sildenafil and Exercise Capacity in Heart Failure—In Reply

Margaret M. Redfield, MD1; Barry A. Borlaug, MD1
[+] Author Affiliations
1Heart Failure Clinical Research Network, Mayo Clinic, Rochester, Minnesota
JAMA. 2013;310(4):432-433. doi:10.1001/jama.2013.7440.
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In Reply Dr Guazzi and colleagues suggest that the presence of comorbidities such as obesity, atrial dysrhythmias, and anemia might have made patients with HFPEF less apt to derive benefit from phosphodiesterase-5 inhibition. These comorbidities are typical in patients with HFPEF in the community.1 Heart failure with normal EF in the absence of comorbidities is usually termed restrictive cardiomyopathy, and this is a much less common form of HF than the type that we set out to study in the RELAX trial.

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July 24, 2013
Marco Guazzi, MD, PhD; Francesco Bandera, MD; Paul Forfia, MD
1Heart Failure Unit, San Donato University Hospital, Milan, Italy
2Pulmonary Hypertension and Right Heart Failure Program, Temple Heart and Vascular Center, Philadelphia, Pennsylvania
JAMA. 2013;310(4):432. doi:10.1001/jama.2013.7437.
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