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Comment and Response |

Chelation Therapy and Cardiovascular Outcomes

Bruce Kleinman, MD1
[+] Author Affiliations
1Department of Anesthesiology, Edward Hines Jr VA Hospital, Hines, Illinois
JAMA. 2013;310(4):431. doi:10.1001/jama.2013.7930.
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To The Editor The Trial to Assess Chelation Therapy (TACT) concluded that chelation therapy modestly reduced the risk of adverse cardiac outcomes.1 Dr Nissen, in his Editorial,2 pointed out that despite TACT being a randomized clinical trial (the criterion standard for clinical research), not all randomized clinical trials are equal. Likewise, Browner and Newman3 (almost 30 years ago) pointed out that not all significant P values are equal.

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July 24, 2013
Gervasio A. Lamas, MD; Daniel Mark, MD, MPH; Kerry L. Lee, PhD
1Division of Cardiology, Columbia University at Mount Sinai Medical Center, Miami Beach, Florida
2Duke Clinical Research Institute, Durham, North Carolina
JAMA. 2013;310(4):431-432. doi:10.1001/jama.2013.7954.
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