Study concept and design: Harjutsalo, Sund, Knip, Groop.
Acquisition of data: Harjutsalo, Sund, Knip.
Analysis and interpretation of data: Harjutsalo, Sund, Knip, Groop.
Drafting of the manuscript: Harjutsalo, Groop.
Critical revision of the manuscript for important intellectual content: Harjutsalo, Sund, Knip, Groop.
Statistical analysis: Harjutsalo, Sund.
Obtained funding: Groop.
Administrative, technical, or material support: Sund.
Study supervision: Knip, Groop.
Conflict of Interest Disclosures: The authors have completed and submitted the ICMJE Form for Disclosure of Potential Conflicts of Interest. Dr Knip reported receiving lecture honoraria from Novo Nordisk; serving on the board for Vactech Ltd, a small biotech company developing vaccines against picornaviruses; and being a minor (<5%) shareholder of Vactech. Dr Groop reported receiving lecture honoraria from Boehringer Ingelheim, Genzyme, Novartis, Novo Nordisk, Merck Sharp Dohme Finland, Eli Lilly, and Medscape; serving on an advisory board for Boehringer Ingelheim, Novartis, and Medscape; receiving investigator-initiated study grants from Eli Lilly and Roche; institutional grants from the Folkhälsan Research Foundation and the Wilhelm and Else Stockmann Foundation; and receiving payment for the development of educational presentations from Medscape. No other disclosures were reported.
Funding/Support: This research was supported by grants from the Folkhälsan Research Foundation, the Wilhelm and Else Stockmann Foundation, the Academy of Finland (134379), and the Liv och Hälsa Foundation.
Role of the Sponsor: The sponsors had no role in the design and conduct of the study; collection, management, analysis, and interpretation of the data; and preparation, review, or approval of the manuscript; and decision to submit the manuscript for publication.