Comment and Response |

Myocardial Thinning in Patients With Coronary Artery Disease

Neng Dai, MD1; Da-Chun Xu, MD, PhD1; Ya-Wei Xu, MD, PhD1
[+] Author Affiliations
1Tenth People’s Hospital of Tongji University, Shanghai, China
JAMA. 2013;310(2):207. doi:10.1001/jama.2013.7921.
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To the Editor The study by Dr Shah and colleagues1 reported that among patients with coronary artery disease (CAD), limited scar burden was present in 18% of the patients with regional wall thinning detected by cardiovascular magnetic resonance (CMR) imaging, which challenges common assumptions. We believe some other considerations should be taken into account.

First, a prior study2 revealed that most infarct healing (in terms of reduction in infarct size and wall thinning) was completed by 5 months after a myocardial infarction (MI); however, another study3 indicated that 4 months is most likely too early to detect the full extent of regional and global left ventricular remodeling. Therefore, controversy exists regarding the time course of myocardial thinning after an ischemic event. In the study by Shah et al,1 the time span between diagnosis of CAD and assessment by delayed-enhancement CMR imaging was not mentioned.


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July 10, 2013
Dipan J. Shah, MD; Han W. Kim, MD; Raymond J. Kim, MD
1Methodist DeBakey Heart and Vascular Center, Houston, Texas
2Duke Cardiovascular Magnetic Resonance Center, Duke University Medical Center, Durham, North Carolina
JAMA. 2013;310(2):207-208. doi:10.1001/jama.2013.7936.
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