We're unable to sign you in at this time. Please try again in a few minutes.
We were able to sign you in, but your subscription(s) could not be found. Please try again in a few minutes.
There may be a problem with your account. Please contact the AMA Service Center to resolve this issue.
Contact the AMA Service Center:
Telephone: 1 (800) 262-2350 or 1 (312) 670-7827  *   Email: subscriptions@jamanetwork.com
Error Message ......
Editorial |

In Vitro Fertilization and Risk of Autistic Disorder and Mental Retardation

Marcelle I. Cedars, MD1
[+] Author Affiliations
1Division of Reproductive Endocrinology and Infertility, University of California-San Francisco
JAMA. 2013;310(1):42-43. doi:10.1001/jama.2013.7223.
Text Size: A A A
Published online


The birth of the first infant conceived through in vitro fertilization (IVF) occurred 35 years ago.1 The early focus of IVF programs was on enhancing success rates and optimizing clinical and laboratory techniques in an effort to improve chances of pregnancy. Currently, more than 40%2 of young couples conceive on a single trial of IVF compared with less than 20% in the 1980s.3 In 2012, the number of infants born worldwide as a result of these technologies was 5 million. These numbers will continue to increase with 350 000 infants born annually as a result of an estimated 1.5 million IVF cycles.4 The percentage of total births resulting from IVF is currently 1.4% (>60 000 infants/y) in the United States5 and 0.5% to 4.4% (>100 000 infants/y) in western Europe.6 Therefore, the success of IVF suggests it is important to shift the focus to the safety of the procedure for children.

Sign in

Purchase Options

• Buy this article
• Subscribe to the journal
• Rent this article ?

First Page Preview

View Large
First page PDF preview




Also Meets CME requirements for:
Browse CME for all U.S. States
Accreditation Information
The American Medical Association is accredited by the Accreditation Council for Continuing Medical Education to provide continuing medical education for physicians. The AMA designates this journal-based CME activity for a maximum of 1 AMA PRA Category 1 CreditTM per course. Physicians should claim only the credit commensurate with the extent of their participation in the activity. Physicians who complete the CME course and score at least 80% correct on the quiz are eligible for AMA PRA Category 1 CreditTM.
Note: You must get at least of the answers correct to pass this quiz.
Please click the checkbox indicating that you have read the full article in order to submit your answers.
Your answers have been saved for later.
You have not filled in all the answers to complete this quiz
The following questions were not answered:
Sorry, you have unsuccessfully completed this CME quiz with a score of
The following questions were not answered correctly:
Commitment to Change (optional):
Indicate what change(s) you will implement in your practice, if any, based on this CME course.
Your quiz results:
The filled radio buttons indicate your responses. The preferred responses are highlighted
For CME Course: A Proposed Model for Initial Assessment and Management of Acute Heart Failure Syndromes
Indicate what changes(s) you will implement in your practice, if any, based on this CME course.


Some tools below are only available to our subscribers or users with an online account.

5 Citations

Sign in

Purchase Options

• Buy this article
• Subscribe to the journal
• Rent this article ?

Related Content

Customize your page view by dragging & repositioning the boxes below.

See Also...
Articles Related By Topic
Related Collections
PubMed Articles