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Fibrosis and Mortality in Patients With Dilated Cardiomyopathy—Reply

Ankur Gulati, MD; Tevfik F. Ismail, MD; Sanjay K. Prasad, MD
JAMA. 2013;309(24):2547-2549. doi:10.1001/jama.2013.6467.
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In Reply: The latest international heart failure guidelines identify more than 50 potential prognostic variables for patients with heart failure.1 However, although these parameters have been shown to provide independent prognostic value, there is no consistency among studies regarding the covariates used in multivariate modeling.

Furthermore, the incremental prognostic value has not been ascertained for most variables. Even though a number of risk prediction models incorporating many of these factors have been proposed, their complexity and varying availability of the constituent variables mean that they are not routinely used in clinical practice.2

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June 26, 2013
Andrea Barison, MD; Pier Giorgio Masci, MD; Michele Emdin, MD, PhD
JAMA. 2013;309(24):2547. doi:10.1001/jama.2013.6453.
June 26, 2013
Maarten J. G. Leening, MD, MSc; Ewout W. Steyerberg, PhD
JAMA. 2013;309(24):2547-2549. doi:10.1001/jama.2013.6470.
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