Author Contributions: Dr Saver had full access to all of the data in the study and takes responsibility for the integrity of the data and the accuracy of the data analysis.
Study concept and design: Fonarow, Reeves, Grau-Sepulveda, Olson, Hernandez, Peterson, Schwamm, Saver.
Acquisition of data: Fonarow, Reeves, Grau-Sepulveda, Olson, Hernandez, Peterson, Saver.
Analysis and interpretation of data: Fonarow, Smith, Reeves, Grau-Sepulveda, Pan, Olson, Hernandez, Peterson, Saver.
Drafting of the manuscript: Reeves, Grau-Sepulveda, Olson, Hernandez, Peterson, Saver.
Critical revision of the manuscript for important intellectual content: Fonarow, Smith, Reeves, Grau-Sepulveda, Pan, Olson, Hernandez, Peterson, Schwamm.
Statistical analysis: Reeves, Grau-Sepulveda, Pan, Olson, Hernandez, Peterson, Saver.
Obtained funding: Fonarow, Reeves, Grau-Sepulveda, Olson, Hernandez, Peterson.
Administrative, technical, or material support: Fonarow, Smith, Reeves, Grau-Sepulveda, Olson, Hernandez, Peterson, Schwamm.
Study supervision: Fonarow, Reeves, Grau-Sepulveda, Olson, Hernandez, Peterson, Schwamm, Saver.
Conflict of Interest Disclosures: All authors have completed and submitted the ICMJE Form for Disclosure of Potential Conflicts of Interest. Dr Saver reports serving as a member of the Get With the Guidelines (GWTG) Science Subcommittee; as a scientific consultant regarding trial design and conduct to Covidien, CoAxia, Grifols, Brainsgate, Lundbeck, and St Jude Medical; receipt of a grant or pending grant (to the institution) from the National Institutes of Health (NIH)-National Institute of Neurological Disorders and Stroke (NINDS); and being an employee of the University of California, which holds a patent on retriever devices for stroke. Dr Fonarow reports serving as a member of the GWTG Steering Committee; receipt of research support (to the institution) from NIH; and being an employee of the University of California. Dr Smith reports having served on an advisory board to Genentech and being on the data safety and monitoring board for the MR WITNESS trial. Dr Reeves reports receiving salary support from the Michigan Stroke Registry and serving as a member of the American Heart Association (AHA) GWTG Quality Improvement Subcommittee. Drs Grau-Sepulveda, Pan, and Hernandez report being members of the Duke Clinical Research Institute (DCRI), which serves as the AHA GWTG data coordinating center. Dr Olson reports provision of writing assistance, medicines, equipment, or administrative support from DCRI. Dr Hernandez reports being a recipient of an AHA Pharmaceutical Roundtable grant and having received research support from Johnson & Johnson and Amylin. Dr Peterson reports serving as principal investigator of the Data Analytic Center for AHA GWTG; receipt of research grants from Johnson & Johnson, Eli Lilly, and Janssen Pharmaceuticals; and serving as a consultant to Boehringer Ingelheim, Johnson & Johnson, Medscape, Merck, Novartis, Ortho-McNeil-Janssen, Pfizer, Westat, the Cardiovascular Research Foundation, WebMD, and United Healthcare. Dr Schwamm reports serving as chair of the AHA GWTG Steering Committee; as a consultant to the Massachusetts Department of Public Health, Lundbeck, and to the Joint Commission; and provision of alteplase to Massachusetts General Hospital for a NINDS-funded multicenter study of extended window thrombolysis in magnetic resonance–guided patient selection from Genentech. No other disclosures were reported.
Funding/Support: The GWTG-Stroke Program is provided by the AHA/American Stroke Association. The GWTG-Stroke Program is currently supported in part by a charitable contribution from Janssen Pharmaceutical Companies of Johnson & Johnson. The GWTG-Stroke Program has been funded in the past through support from Boehringer-Ingelheim, Merck, Bristol-Myers Squib/Sanofi Pharmaceutical Partnership, and the AHA Pharmaceutical Roundtable.
Role of the Sponsor: The industry sponsors of the GWTG-Stroke Program had no role in the design and conduct of the study; in the collection, analysis, and interpretation of the data; or in the preparation, review, or approval of the manuscript; and decision to submit the manuscript for publication.
Disclaimer: Dr Peterson, a contributing editor for JAMA, was not involved in the editorial review of or the decision to publish this article.
Online-Only Material: The Author Audio Interview is available here.