In Reply: The studies referred to by Drs Vahabzadeh and McDougle identified signs of aberrant folate-dependent metabolism and an increased occurrence of folate receptor autoantibodies in children with autism spectrum disorders. We agree that investigations of these mechanisms should be a priority in future research on autism spectrum disorders. However, they are just 2 of several potential explanations.
Folate is a vital co-factor in DNA synthesis, DNA repair, and DNA methylation, and there are multiple ways in which fetal brain development could potentially be influenced by a lack of folate or a reduced ability to use available folate. Consequently, the analytic approach has to be broad and include both genetic and epigenetic analyses, as well as analyses of folate and other related metabolites in blood plasma.
Some tools below are only available to our subscribers or users with an online account.
Download citation file:
Web of Science® Times Cited: 1
Customize your page view by dragging & repositioning the boxes below.
More Listings atJAMACareerCenter.com >
Enter your username and email address. We'll send you a link to reset your password.
Enter your username and email address. We'll send instructions on how to reset your password to the email address we have on record.
Athens and Shibboleth are access management services that provide single sign-on to protected resources. They replace the multiple user names and passwords necessary to access subscription-based content with a single user name and password that can be entered once per session. It operates independently of a user's location or IP address. If your institution uses Athens or Shibboleth authentication, please contact your site administrator to receive your user name and password.