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End Points in Trials of Treatments for Skin Infections—Reply

Philippe Prokocimer, MD; Anita Das, PhD
JAMA. 2013;309(20):2091-2092. doi:10.1001/jama.2013.4550.
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In Reply: Dr Spellberg raises the question of whether a cessation of lesion spread in ABSSSIs can be considered a cure of the disease. This issue was discussed by the Foundation for the National Institutes of Health working group on end points in ABSSSIs.1 The group's recommended end point is a 20% or greater decrease in lesion size at the 48- to 72-hour assessment rather than cessation of spread at this time point.

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May 22, 2013
Brad Spellberg, MD
JAMA. 2013;309(20):2091-2092. doi:10.1001/jama.2013.4541.
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