JAMA Clinical Challenge | Clinician's Corner

Sudden Purpuriform Rash in an Infant

Helene Sophie Scheer; Lisa Weibel, MD
JAMA. 2013;309(20):2159-2160. doi:10.1001/jama.2013.4794.
Text Size: A A A
Published online


A 10-month-old boy presents with erythematous swelling of bothears and right eyelid and erythematous perioral macules following a respiratory tract infection 12 days before presentation (Figure, A). Within 4 days the lesions increased in size, becoming large erythematous plaques on the face (Figure, B). Targetoid, purpuric lesions developed on the limbs (Figure, C), along with hand edema. There were no trunk lesions and no involvement of the mucous membranes. The child is otherwise in good general health. On examination he is afebrile, has normal vital signs, and there is no lymphadenopathy or organomegaly. Findings from urinalysis, complete blood cell count, coagulation studies, and liver and kidney function studies are unremarkable.

Figures in this Article

Sign In to Access Full Content

Don't have Access?

Register and get free email Table of Contents alerts, saved searches, PowerPoint downloads, CME quizzes, and more

Subscribe for full-text access to content from 1998 forward and a host of useful features

Activate your current subscription (AMA members and current subscribers)

Purchase Online Access to this article for 24 hours

First Page Preview

View Large
First page PDF preview


Place holder to copy figure label and caption
Figure. A, Erythematous swelling of ears and right eyelid and erythematous perioral macules at presentation. B, Large erythematous plaques on the face 4 days after presentation. C, Purpuric lesions in targetoid pattern on lower limbs.
Graphic Jump Location



Meets CME requirements for:
Browse CME for all U.S. States
Accreditation Information
The American Medical Association is accredited by the Accreditation Council for Continuing Medical Education to provide continuing medical education for physicians. The AMA designates this journal-based CME activity for a maximum of 1 AMA PRA Category 1 CreditTM per course. Physicians should claim only the credit commensurate with the extent of their participation in the activity. Physicians who complete the CME course and score at least 80% correct on the quiz are eligible for AMA PRA Category 1 CreditTM.
Note: You must get at least of the answers correct to pass this quiz.
You have not filled in all the answers to complete this quiz
The following questions were not answered:
Sorry, you have unsuccessfully completed this CME quiz with a score of
The following questions were not answered correctly:
Commitment to Change (optional):
Indicate what change(s) you will implement in your practice, if any, based on this CME course.
Your quiz results:
The filled radio buttons indicate your responses. The preferred responses are highlighted
For CME Course: A Proposed Model for Initial Assessment and Management of Acute Heart Failure Syndromes
Indicate what changes(s) you will implement in your practice, if any, based on this CME course.
Citing articles are presented as examples only. In non-demo SCM6 implementation, integration with CrossRef’s "Cited By" API will populate this tab (http://www.crossref.org/citedby.html).


Some tools below are only available to our subscribers or users with an online account.

Sign In to Access Full Content

Related Content

Customize your page view by dragging & repositioning the boxes below.

Articles Related By Topic
Related Topics