Published Online: May 21, 2013. doi:10.1001/jama.2013.5827
Author Contributions: Dr Peljto had full access to the data in the study and takes responsibility for the integrity of the data and the accuracy of the data analysis. Drs Peljto and Zhang contributed equally as first authors and Drs Noth, M. I. Schwarz, Kaminski, and D. A. Schwartz contributed equally as last authors.
Study concept and design: Fingerlin, Garcia, Lindell, Loyd, Noth, Schwarz, Kaminski, Schwartz.
Acquisition of data: Zhang, Ma, Lindell, Steele, Gibson, Brown, Talbert, Markin, Kossen, Murphy, Noth, Schwarz, Kaminski, Schwartz.
Analysis and interpretation of data: Peljto, Fingerlin, Ma, Richards, Silveira, Loyd, Seibold, Brown, Talbert, Kossen, Seiwert, Noth, Schwarz, Kaminski, Schwartz.
Drafting of the manuscript: Peljto, Fingerlin, Richards, Silveira, Gibson, Markin, Noth, Schwarz, Kaminski, Schwartz.
Critical revision of the manuscript for important intellectual content: Peljto, Zhang, Fingerlin, Ma, Garcia, Richards, Lindell, Steele, Loyd, Seibold, Brown, Talbert, Kossen, Seiwert, Murphy, Kaminski, Schwartz.
Statistical analysis: Peljto, Fingerlin, Ma, Richards, Silveira, Noth, Schwartz.
Obtained funding: Seiwert, Noth, Schwarz, Kaminski, Schwartz.
Administrative, technical, or material support: Zhang, Lindell, Steele, Loyd, Gibson, Brown, Talbert, Markin, Seiwert, Murphy, Schwartz.
Study supervision: Fingerlin, Loyd, Schwarz, Kaminski, Schwartz.
Conflict of Interest Disclosures: All authors have completed and submitted the ICMJE Form for Disclosure of Potential Conflicts of Interest. Drs Seibold and D. A. Schwartz have filed a patent for MUC5B genetic variants, methods, and compositions for risk prediction, diagnosis, prognosis, and treatment of pulmonary disorders. Drs Kossen and Seiwert are employee shareholders of InterMune Inc, which is pursuing a license to the aforementioned patent, and have filed patents on use of peripheral blood biomarkers in IPF. Dr Noth has contracts for clinical trials with Boehringer Ingelheim, Sanofi, and Stromedix; has served on the speakers' bureau of GlaxoSmithKline; is a consultant to Boehringer Ingelheim and Immuneworks; and has patents related to gene expression profiling and plasma proteins. Dr Kaminski is a consultant to Sanofi, InterMune, Stromedix, Celgene, Promedior, and Vertex; is a recipient of investigator-initiated research grants from Gilead, Celgene, and Centocor; and has filed a patent on use of peripheral blood biomarkers in IPF. No other disclosures were reported.
Funding/Support: This research was supported by the National Heart, Lung, and Blood Institute (grants R01-HL095393, R01-HL097163, R01-HL095397, P50-HL0894932, P01-HL092870, RC1-HL09961, and RC2-HL101715) and the Dorothy P. and Richard P. Simmons Endowed Chair for Pulmonary Research (University of Pittsburgh School of Medicine).
Role of the Sponsor: The funders had no role in the design and conduct of the study; collection, management, analysis, and interpretation of the data; preparation, review, or approval of the manuscript; and decision to submit the manuscript for publication.
Additional Contributions: We gratefully appreciate all participating IPF patients for their contributions to IPF research.