Author Contributions: Dr Gasparini had full access to all of the data in the study and takes responsibility for the integrity of the data and the accuracy of the data analysis.
Study concept and design: Gasparini, Proclemer, Lunati, Wijffels, Santi, Manotta, Arenal.
Acquisition of data: Gasparini, Proclemer, Kloppe, Ferrer, Hersi, Gulaj, Wijffels, Arenal.
Analysis and interpretation of data: Gasparini, Proclemer, Klersy, Kloppe, Lunati, Hersi.
Drafting of the manuscript: Gasparini, Proclemer, Klersy, Arenal.
Critical revision of the manuscript for important intellectual content: All authors.
Statistical analysis: Klersy.
Administrative, technical, or material support: Santi, Manotta.
Study supervision: Proclemer, Kloppe, Lunati, Gasparini.
Conflict of Interest Disclosures: All authors have completed and submitted the ICMJE Form for Disclosure of Potential Conflicts of Interest. Dr Gasparini reports serving on the advisory board for Medtronic and Boston SCI. Dr Proclemer reports serving on the advisory board for Medtronic. Dr Klersy reports serving as a statistical consultant for Medtronic. Dr Kloppe reports serving as speaker for Medtronic. Dr Martínez Ferrer reports serving as lecturer and consultant for Medtronic. Dr Lunati reports serving as a consultant for Medtronic, Sorin, Boston SCI, and St Jude Medical. Dr Hersi reports serving as a lecturer for Boehringer-Ingelheim. Dr Gulaj reports serving as a consultant for Biotronik, Medtronic, and Boston SCI, and as a lecturer for Medtronic. Dr Wijffels reports serving as proctor and lecturer for Medtronic. Dr Arenal reports serving as a consultant for Boston SCI and receiving a grant from Biosense-Webster.
Funding/Support: The ADVANCE III study was supported financially by Medtronic Inc.
Role of the Sponsor: Medtronic participated in the design, conduct, and management of the study but had no role in the collection of data; Medtronic participated in review and approval of the manuscript but had no role in the analysis, interpretation of data, or editing of the manuscript.
Independent Statistical Analysis: The statistical analysis of the ADVANCE III data was performed by C. Klersy, MD, MSc, an independent statistician (and author) who had access to the full data set
Additional Contributions: We dedicate this article to the late Professor Andrzej Okreglicki, MD. The ADVANCE III team is grateful for having had the chance to work with a scientist of such expertise and professionalism. His contributions to the work of the steering committee were an example to the whole team. We thank Joerg O. Schwab, MD, FESC, Bernd Kaup, Giuseppe Ligorio, João de Sousa, MD, and Bernd Lemke, MD, for their input.
This article was corrected for errors on May 7, 2013.