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Differential Effects of Fructose and Glucose on Cerebral Blood Flow

David Driscoll, BSc, MSc
JAMA. 2013;309(17):1768. doi:10.1001/jama.2013.3364.
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To the Editor: Even though the changes in brain activity and cerebral blood flow after ingestion of fructose and glucose are interesting, additional information on actual physical manifestations of those changes is required to make recommendations, as noted by Dr Page and colleagues.1

They stated that “There was no significant difference between glucose vs fructose ingestion on predrink-postdrink changes in hunger (mean difference, 0.7 [95% CI, −0.4 to 1.7]; P = .22), fullness (mean difference, −0.9 [95% CI, −2.1 to 0.2]; P = .09), or satiety (mean difference, −1.0 [95% CI, −2.3 to 0.4]; P = .15).” However, they reported a significant predrink to postdrink difference in fullness and satiety with glucose but not fructose.


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May 1, 2013
Steve Hertzler, PhD, RD, LD
JAMA. 2013;309(17):1768. doi:10.1001/jama.2013.3358.
May 1, 2013
Kathleen A. Page, MD; Rajita Sinha, PhD; Robert S. Sherwin, MD
JAMA. 2013;309(17):1768. doi:10.1001/jama.2013.3367.
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