Author Contributions: Drs Assmus and Zeiher had full access to all of the data in the study and take responsibility for the integrity of the data and the accuracy of the data analysis. Drs Assmus and Walter contributed equally to the manuscript.
Study concept and design: Assmus, Walter, Lutz, Khaled, Dimmeler, Zeiher.
Acquisition of data: Assmus, Walter, Seeger, Leistner, Steiner, Ziegler, Khaled, Tonn, Zeiher.
Analysis and interpretation of data: Assmus, Walter, Klotsche, Tonn, Zeiher.
Drafting of the manuscript: Assmus, Walter, Lutz, Dimmeler, Zeiher.
Critical revision of the manuscript for important intellectual content: Assmus, Walter, Seeger, Leistner, Steiner, Ziegler, Khaled, Klotsche, Tonn, Dimmeler, Zeiher.
Statistical analysis: Assmus, Walter, Klotsche.
Obtained funding: Dimmeler, Zeiher.
Administrative, technical, or material support: Seeger, Steiner, Lutz, Khaled, Tonn, Dimmeler, Zeiher.
Study supervision: Assmus, Walter, Zeiher.
Conflict of Interest Disclosures: All authors have completed and submitted the ICMJE Form for Disclosure of Potential Conflicts of Interest. Dr Dimmeler and Dr Zeiher report that they are cofounders of t2cure, a for-profit company focused on regenerative therapies for cardiovascular disease, and for which they serve as scientific advisers and are shareholders. Dr Dimmeler reported serving on a scientific advisory board for Miragen; serving as a consultant to Merck; receiving grants or grants pending from the German Research Foundation (DFG) and the European Union; receiving payment for lectures from various entities; holding patents or patents pending (miR-29, miR-92); and receiving travel expenses from various entities. Dr Zeiher reported serving as a consultant to sanofi-aventis, Capricor, and Baxter Healthcare; receiving a grant from the DFG; receiving grants or grants pending from the German Ministry of Health and Education; receiving payment for lectures from Bayer, Berlin Chemie, Orbus Neich, and AstraZeneca; and holding patents or patents pending from Siemens Healthcare. No other authors reported disclosures.
Funding/Support: This study was supported by an unrestricted grant to the Goethe University Frankfort from t2cure GmbH.
Role of the Sponsor: The Goethe University Frankfurt and t2cure GmbH had no role in the design and conduct of the study; the collection, analysis, and interpretation of the data; or the preparation, review, or approval of the manuscript.
Additional Contributions: We thank Stephanie Estel, Heike Wagner, and Isabell Geweyer (Division of Cardiology, Department of Medicine III, Goethe University, Frankfurt, Germany), for their excellent trial organization and expert assistance. We also thank Petra Rueck, PhD (t2cure GmbH, Frankfurt), for trial assistance and data monitoring. None of these persons received any trial-specific financial compensation.
This article was corrected for errors on April 16, 2013.