Author Contributions: Ms Mandyam and Dr Marcus had full access to all of the data in the study and take responsibility for the integrity of the data and the accuracy of the data analysis.
Study concept and design: Mandyam, Soliman, Marcus.
Acquisition of data: Mandyam, Soliman, Heckbert.
Analysis and interpretation of data: Mandyam, Heckbert, Vittinghoff, Marcus.
Drafting of the manuscript: Mandyam, Marcus.
Critical revision of the manuscript for important intellectual content: Mandyam, Soliman, Heckbert, Vittinghoff.
Statistical analysis: Mandyam, Vittinghoff, Marcus.
Obtained funding: Mandyam, Heckbert.
Administrative, technical, or material support: Mandyam.
Study supervision: Marcus.
Conflict of Interest Disclosures: The authors have completed and submitted the ICMJE Form for Disclosure of Potential Conflicts of Interest. Dr Heckbert reported receiving grants from the National Heart, Lung, and Blood Institute. Dr Vittinghoff reported receiving support for statistical consulting from the National Institutes of Health. No other disclosures were reported.
Funding/Support: This publication was supported by the National Center for Research Resources, the National Center for Advancing Translational Sciences, and the Office of the Director, National Institutes of Health, through grant TL1 RR024129. This research was also supported by contracts HHSN268201200036C, N01HC85239, N01 HC55222, N01HC85079, N01HC85080, N01HC85081, N01HC85082, N01HC85083, N01HC85086, and grants HL080295 and HL068986 from the National Heart, Lung, and Blood Institute, with additional contribution from the National Institute of Neurological Disorders and Stroke. Additional support was provided by grant AG023629 from the National Institute on Aging and the Joseph Drown Foundation. A full list of principal Cardiovascular Health Study investigators and institutions can be found at http://www.chs-nhlbi.org /PI.htm.
Role of the Sponsors: The funding organizations were not involved in the design or conduct of the study; collection, management, analysis, or interpretation of the data; or preparation, review, or approval of the manuscript.
Disclaimer: The contents of this publication are solely the responsibility of the authors and do not necessarily represent the official views of the National Institutes of Health.