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Vitamin D Supplementation in Patients With Osteoarthritis

Changhai Ding, MD; Flavia Cicuttini, PhD; Graeme Jones, MD
JAMA. 2013;309(15):1583-1584. doi:10.1001/jama.2013.3775.
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To the Editor: Dr McAlindon and colleagues1 reported that vitamin D supplementation for 2 years at a dose sufficient to elevate 25-hydroxyvitamin D plasma levels to higher than 36 ng/mL did not reduce knee pain or cartilage volume loss in patients with symptomatic knee osteoarthritis. However, this study has several potential limitations that might make the conclusions problematic.

First, the study included both patients with vitamin D sufficiency and deficiency. In those with low baseline 25-hydroxyvitamin D (≤15 ng/mL), vitamin D supplementation had larger effects on knee pain and change in cartilage volume than in those who received placebo, although these were not significant due to small sample size. In those with higher 25-hydroxyvitamin D levels, vitamin D supplementation had no effect.

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April 17, 2013
Timothy McAlindon, DM, MPH; Michael LaValley, PhD; Bess Dawson-Hughes, MD
JAMA. 2013;309(15):1583-1584. doi:10.1001/jama.2013.3778.
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