Author Contributions: Dr Mayeux had full access to all of the data in the study and takes responsibility for the integrity of the data and the accuracy of the data analysis.
Study concept and design: Reitz, Buxbaum, Fallin, Griffith, Obisesan, Manly, Bennett, Haines, Farrer, Pericak-Vance, Schellenberg, Mayeux.
Acquisition of data: Reitz, Valladares, Lin, Larson, Graff-Radford, Evans, Crane, Buxbaum, Murrell, Ertekin-Taner, Baldwin, Green, Barnes, Cantwell, Fallin, Go, Obisesan, Manly, Kamboh, Lopez, Bennett, Hendrie, Hall, Goate, Byrd, Kukull, Foroud, Haines, Farrer, Pericak-Vance, Schellenberg, Mayeux.
Analysis and interpretation of data: Reitz, Jun, Naj, Rajbhandary, Vardarajan, Wang, Valladares, Graff-Radford, De Jager, Crane, Buxbaum, Raj, Ertekin-Taner, Logue, Manly, Lunetta, Bennett, Hendrie, Farrer, Pericak-Vance, Schellenberg, Mayeux.
Drafting of the manuscript: Reitz, Naj, De Jager, Raj, Cantwell, Pericak-Vance, Mayeux.
Critical revision of the manuscript for important intellectual content: Reitz, Jun, Naj, Rajbhandary, Vardarajan, Wang, Valladares, Lin, Larson, Graff-Radford, Evans, Crane, Buxbaum, Murrell, Ertekin-Taner, Logue, Baldwin, Green, Barnes, Fallin, Go, Griffith, Obisesan, Manly, Lunetta, Kamboh, Lopez, Bennett, Hendrie, Hall, Goate, Byrd, Kukull, Foroud, Haines, Farrer, Pericak-Vance, Schellenberg, Mayeux.
Statistical analysis: Reitz, Jun, Naj, Rajbhandary, Vardarajan, Raj, Logue, Hall, Lunetta, Hendrie, Haines, Farrer, Pericak-Vance.
Obtained funding: Larson, Evans, Murrell, Green, Barnes, Fallin, Go, Manly, Kamboh, Bennett, Goate, Byrd, Haines, Pericak-Vance, Schellenberg, Mayeux.
Administrative, technical, or material support: Naj, Wang, Valladares, Lin, Larson, Crane, Buxbaum, Murrell, Ertekin-Taner, Baldwin, Green, Cantwell, Fallin, Obisesan, Kamboh, Lopez, Bennett, Hall, Goate, Byrd, Kukull, Foroud, Farrer, Schellenberg, Mayeux.
Study supervision: Go, Obisesan, Bennett, Hendrie, Byrd, Foroud, Farrer, Schellenberg, Mayeux.
Conflict of Interest Disclosures: All authors have completed and submitted the ICMJE Form for Disclosure of Potential Conflicts of Interest. Dr Baldwin reported serving as a consultant for the Center for Human Genetics Inc. Dr Go reported receiving travel support from the National Institutes of Health (NIH). Dr Griffith reported receiving payment for lectures from Eisai and Pfizer. Dr Manly reported serving as a board member for the International Neuropsychological Society; receiving grants or grants pending from the Alzheimer's Association and the National Institute on Aging (NIA); and receiving travel expenses from the Alzheimer's Association. Dr Kamboh reported receiving travel support from the NIH. Dr Lopez reported receiving consulting fees or honoraria from Mertz and Lundbeck. Dr Bennett reported receiving travel support from the NIH. Dr Goate reported serving as a consultant for Finnegan; providing expert testimony in cases involving the genetics of Alzheimer disease; receiving grants or grants pending from Genentech and Pfizer; receiving payment for lectures from Pfizer, Genentech, and Amgen; and receiving patent royalties from Taconic for a tau mutation. Dr Pericak-Vance reported receiving revenues from Athena Diagnostics. No other authors reported disclosures.
Funding/Support: The NIA supported this work through grants U01-AG032984, RC2-AG036528, U01-AG016976 (Dr Kukull); U24 AG026395, U24 AG026390, R01AG037212, R37 AG015473 (Dr Mayeux); K23AG034550 (Dr Reitz); U24-AG021886 (Dr Foroud); R01AG009956, RC2 AG036650 (Dr Hall); UO1 AG06781, UO1 HG004610 (Dr Larson); R01 AG009029 (Dr Farrer); 5R01AG20688 (Dr Fallin); P50 AG005133, AG030653 (Dr Kamboh); R01 AG019085 (Dr Haines); R01 AG1101, R01 AG030146, RC2 AG036650 (Dr Evans); P30AG10161, R01AG15819, R01AG30146, R01AG17917, R01AG15819 (Dr Bennett); R01AG028786 (Dr Manly); R01AG22018, P30AG10161 (Dr Barnes); P50AG16574 (Dr Ertekin-Taner, Dr Graff-Radford), R01 AG032990 (Dr Ertekin-Taner), KL2 RR024151 (Dr Ertekin-Taner); R01 AG027944, R01 AG028786 (Dr Pericak-Vance); P20 MD000546, R01 AG28786-01A1 (Dr Byrd); AG005138 (Dr Buxbaum); P50 AG05681, P01 AG03991, P01 AG026276 (Dr Goate); and P30AG019610, P30AG13846, U01-AG10483, R01CA129769, R01MH080295, R01AG017173, R01AG025259, R01AG33193, P50AG008702, P30AG028377, AG05128, AG025688, P30AG10133, P50AG005146, P50AG005134, P01AG002219, P30AG08051, MO1RR00096, UL1RR029893, P30AG013854, P30AG008017, R01AG026916, R01AG019085, P50AG016582, UL1RR02777, R01AG031581, P30AG010129, P50AG016573, P50AG016575, P50AG016576, P50AG016577, P50AG016570, P50AG005131, P50AG023501, P50AG019724, P30AG028383, P50AG008671, P30AG010124, P50AG005142, P30AG012300, AG010491, AG027944, AG021547, AG019757, P50AG005136 (Alzheimer Disease GeneticsConsortium [ADGC]). We thank Creighton Phelps, Stephen Synder, and Marilyn Miller from the NIA, who are ex-officio members of the ADGC. Support was also provided by the Alzheimer's Association (IIRG-08-89720 [Dr Farrer] and IIRG-05-14147 [Dr Pericak-Vance]), National Institute of Neurological Disorders and Stroke grant NS39764, National Institute of Mental Health grant MH60451, GlaxoSmithKline, and the Office of Research and Development, Biomedical Laboratory Research Program, US Department of Veterans Affairs Administration. For the ADGC, biological samples and associated phenotypic data used in primary data analyses were stored at principal investigators' institutions and at the National Cell Repository for Alzheimer's Disease (NCRAD) at Indiana University, funded by the NIA. Associated phenotypic data used in secondary data analyses were stored at the National Alzheimer's Coordinating Center and at the NIA Alzheimer's Disease Data Storage Site at the University of Pennsylvania, funded by the NIA. Contributors to the genetic analysis data included principal investigators on projects ndividually funded by the NIA, other NIH institutes, or private entities.
Role of the Sponsor: The funding organizations and sponsors had no role in the design and conduct of the study; the collection, management, analysis, and interpretation of the data; or the preparation, review, or approval of the manuscript.
Members of the Alzheimer's Disease Genetics Consortium: Marilyn S. Albert, Roger L. Albin, Liana G. Apostolova, Steven E. Arnold, Robert Barber, Michael M. Barmada, Thomas G. Beach, Gary W. Beecham, Duane Beekly, Eileen H. Bigio, Thomas D. Bird, Deborah Blacker, Bradley F. Boeve, James D. Bowen, Adam Boxer, James R. Burke, Guiqing Cai, Nigel J. Cairns, Chuanhai Cao, Chris S. Carlson, Regina M. Carney, Steven L. Carroll, Helena C. Chui, David G. Clark, David H. Cribbs, Elizabeth A. Crocco, Carlos Cruchaga, Charles DeCarli, Steven T. DeKosky, F. Yesim Demirci, Malcolm Dick, Kelley M. Faber, Kenneth B. Fallon, Martin R. Farlow, Steven Ferris, Matthew P. Frosch, Douglas R. Galasko, Mary Ganguli, Marla Gearing, Daniel H. Geschwind, Bernardino Ghetti, John R. Gilbert, Sid Gilman, Jonathan D. Glass, John H. Growdon, Hakon Hakonarson, Ronald L. Hamilton, Kara L. Hamilton-Nelson, Vahram Haroutunian, Lindy E. Harrell, Elizabeth Head, Lawrence S. Honig, Christine M. Hulette, Bradley T. Hyman, Gail P. Jarvik, Gregory A. Jicha, Lee-Way Jin, Anna Karydas, John S. K. Kauwe, Jeffrey A. Kaye, Ronald Kim, Edward H. Koo, Neil W. Kowall, Joel H. Kramer, Patricia Kramer, Frank M. LaFerla, James J. Lah, Rosalyn Lang-Walker, James B. Leverenz, Allan I. Levey, Ge Li, Andrew P. Lieberman, Constantine G. Lyketsos, Wendy J. Mack, Daniel C. Marson, Eden R. Martin, Frank Martiniuk, Deborah C. Mash, Eliezer Masliah, Wayne C. McCormick, Susan M. McCurry, Andrew N. McDavid, Ann C. McKee, Marsel Mesulam, Bruce L. Miller, Carol A. Miller, Joshua W. Miller, Thomas J. Montine, John C. Morris, John M. Olichney, Joseph E. Parisi, Elaine Peskind, Ronald C. Petersen, Aimee Pierce, Wayne W. Poon, Huntington Potter, Joseph F. Quinn, Ashok Raj, Murray Raskind, Eric M. Reiman, Barry Reisberg, John M. Ringman, Erik D. Roberson, Howard J. Rosen, Roger N. Rosenberg, Mary Sano, Andrew J. Saykin, Julie A. Schneider, Lon S. Schneider, William W. Seeley, Amanda G. Smith, Joshua A. Sonnen, Salvatore Spina, Robert A. Stern, Rudolph E. Tanzi, John Q. Trojanowski, Juan C. Troncoso, Debby W. Tsuang, Vivianna M. Van Deerlin, Linda J. Van Eldik, Harry V. Vinters, Jean Paul Vonsattel, Sandra Weintraub, Kathleen A. Welsh-Bohmer, Jennifer Williamson, Randall L. Woltjer, Clinton B. Wright, Steven G. Younkin, Chang-En Yu, and Lei Yu.
The Author Video Interview is available .
This article was corrected for errors on April 9, 2013.