0
We're unable to sign you in at this time. Please try again in a few minutes.
Retry
We were able to sign you in, but your subscription(s) could not be found. Please try again in a few minutes.
Retry
There may be a problem with your account. Please contact the AMA Service Center to resolve this issue.
Contact the AMA Service Center:
Telephone: 1 (800) 262-2350 or 1 (312) 670-7827  *   Email: subscriptions@jamanetwork.com
Error Message ......
Medical News and Perspectives |

Genomes of Microbes Inhabiting the Body Offer Clues to Human Health and Disease

M. J. Friedrich
JAMA. 2013;309(14):1447-1449. doi:10.1001/jama.2013.2824.
Text Size: A A A
Published online

Extract

When the Human Genome Project revealed that human chromosomes encode a paltry 21 500 genes, far fewer than anticipated, scientists began to think outside the genome to find additional factors that could be involved in the complexities of human health and disease.

They didn't have to look far. The human microbiome, the constellation of microbes living in and on the body, harbors millions of additional genes that contribute to the well-being of their host.

Although much is known about how pathogens contribute to disease, the roles played by the more abundant beneficial and benign members of the microbiome are less well understood. Often this is because it is very difficult or impossible to culture these organisms outside of the human host. Through research in metagenomics, in which genomic analyses of entire microbial communities are carried out, and investigations into host-microbe interactions, researchers are studying the microbial contributions to health and disease and using what they are learning to develop new diagnostic and therapeutic strategies.

Figures in this Article

Sign in

Create a free personal account to sign up for alerts, share articles, and more.

Purchase Options

• Buy this article
• Subscribe to the journal

First Page Preview

View Large
First page PDF preview

Figures

Place holder to copy figure label and caption

Graphic Jump LocationImage not available.

The Human Microbiome Project aims to characterize the microbial communities at various sites in and on the human body (such as the cluster of Staphylococcus aureus bacteria shown here amid nasal epithelial cells) and to analyze the roles of these microbes in human development and physiology.

(Photo credit: Juergen Berger/www.sciencesource.com)

Tables

References

Letters

CME
Meets CME requirements for:
Browse CME for all U.S. States
Accreditation Information
The American Medical Association is accredited by the Accreditation Council for Continuing Medical Education to provide continuing medical education for physicians. The AMA designates this journal-based CME activity for a maximum of 1 AMA PRA Category 1 CreditTM per course. Physicians should claim only the credit commensurate with the extent of their participation in the activity. Physicians who complete the CME course and score at least 80% correct on the quiz are eligible for AMA PRA Category 1 CreditTM.
Note: You must get at least of the answers correct to pass this quiz.
You have not filled in all the answers to complete this quiz
The following questions were not answered:
Sorry, you have unsuccessfully completed this CME quiz with a score of
The following questions were not answered correctly:
Commitment to Change (optional):
Indicate what change(s) you will implement in your practice, if any, based on this CME course.
Your quiz results:
The filled radio buttons indicate your responses. The preferred responses are highlighted
For CME Course: A Proposed Model for Initial Assessment and Management of Acute Heart Failure Syndromes
Indicate what changes(s) you will implement in your practice, if any, based on this CME course.

Multimedia

Some tools below are only available to our subscribers or users with an online account.

Web of Science® Times Cited: 1

Sign in

Create a free personal account to sign up for alerts, share articles, and more.

Purchase Options

• Buy this article
• Subscribe to the journal

Related Content

Customize your page view by dragging & repositioning the boxes below.

Articles Related By Topic
Related Collections
PubMed Articles
Microbiology of aggressive periodontitis. Periodontol 2000 2014;65(1):46-78.
Functional genomics of Lactobacillus casei establishment in the gut. Proc Natl Acad Sci U S A 2014;111(30):E3101-9.
Jobs
JAMAevidence.com


Genome

brightcove.createExperiences();