0
Medical News and Perspectives |

Genomes of Microbes Inhabiting the Body Offer Clues to Human Health and Disease

M. J. Friedrich
JAMA. 2013;309(14):1447-1449. doi:10.1001/jama.2013.2824.
Text Size: A A A
Published online

Extract

When the Human Genome Project revealed that human chromosomes encode a paltry 21 500 genes, far fewer than anticipated, scientists began to think outside the genome to find additional factors that could be involved in the complexities of human health and disease.

They didn't have to look far. The human microbiome, the constellation of microbes living in and on the body, harbors millions of additional genes that contribute to the well-being of their host.

Although much is known about how pathogens contribute to disease, the roles played by the more abundant beneficial and benign members of the microbiome are less well understood. Often this is because it is very difficult or impossible to culture these organisms outside of the human host. Through research in metagenomics, in which genomic analyses of entire microbial communities are carried out, and investigations into host-microbe interactions, researchers are studying the microbial contributions to health and disease and using what they are learning to develop new diagnostic and therapeutic strategies.

Figures in this Article

Sign In to Access Full Content

Don't have Access?

Register and get free email Table of Contents alerts, saved searches, PowerPoint downloads, CME quizzes, and more

Subscribe for full-text access to content from 1998 forward and a host of useful features

Activate your current subscription (AMA members and current subscribers)

Purchase Online Access to this article for 24 hours

First Page Preview

View Large
/>
First page PDF preview

Figures

Place holder to copy figure label and caption

Graphic Jump LocationImage not available.

The Human Microbiome Project aims to characterize the microbial communities at various sites in and on the human body (such as the cluster of Staphylococcus aureus bacteria shown here amid nasal epithelial cells) and to analyze the roles of these microbes in human development and physiology.

(Photo credit: Juergen Berger/www.sciencesource.com)

Tables

References

CME
Meets CME requirements for:
Browse CME for all U.S. States
Accreditation Information
The American Medical Association is accredited by the Accreditation Council for Continuing Medical Education to provide continuing medical education for physicians. The AMA designates this journal-based CME activity for a maximum of 1 AMA PRA Category 1 CreditTM per course. Physicians should claim only the credit commensurate with the extent of their participation in the activity. Physicians who complete the CME course and score at least 80% correct on the quiz are eligible for AMA PRA Category 1 CreditTM.
Note: You must get at least of the answers correct to pass this quiz.
You have not filled in all the answers to complete this quiz
The following questions were not answered:
Sorry, you have unsuccessfully completed this CME quiz with a score of
The following questions were not answered correctly:
Commitment to Change (optional):
Indicate what change(s) you will implement in your practice, if any, based on this CME course.
Your quiz results:
The filled radio buttons indicate your responses. The preferred responses are highlighted
For CME Course: A Proposed Model for Initial Assessment and Management of Acute Heart Failure Syndromes
Indicate what changes(s) you will implement in your practice, if any, based on this CME course.
NOTE:
Citing articles are presented as examples only. In non-demo SCM6 implementation, integration with CrossRef’s "Cited By" API will populate this tab (http://www.crossref.org/citedby.html).

Multimedia

Some tools below are only available to our subscribers or users with an online account.

Web of Science® Times Cited: 1

Sign In to Access Full Content

Related Content

Customize your page view by dragging & repositioning the boxes below.

Articles Related By Topic
Related Topics
PubMed Articles
Jobs
JAMAevidence.com


Genome

brightcove.createExperiences();