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Letters |

Use of Stem Cells for Ischemic Cardiomyopathy

Guo-You Zhang, MD; Qing-Feng Li, MD, PhD; Xiao-Bing Fu, MD, PhD
JAMA. 2013;309(14):1458-1459. doi:10.1001/jama.2013.2890.
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To the Editor: Dr Hare and colleagues1 investigated the efficacy and safety of allogeneic mesenchymal stem cells (MSCs) administered by transendocardial stem cell injection compared with autologous MSCs in patients with chronic left ventricular dysfunction secondary to myocardial infarction. The results are encouraging; however, we have some concerns about the study.

First, because aging impairs the survival and differentiation potential of MSCs, which may limit their therapeutic efficacy,2 what were the screening criteria for donors in the study? Were there any age limits for donors?

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April 10, 2013
Joshua M. Hare, MD; Darcy Difede, RN; Alan W. Heldman, MD
JAMA. 2013;309(14):1458-1459. doi:10.1001/jama.2013.2893.
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