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Letters |

Sustained Virological Response to Treatment in Patients With Chronic Hepatitis C—Reply

Adriaan J. van der Meer, MD; Bettina E. Hansen, PhD; Harry L. A. Janssen, MD, PhD
JAMA. 2013;309(14):1457. doi:10.1001/jama.2013.2733.
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In Reply: Mr Maisonneuve and Dr Bruno raise the possibility that the association between SVR and reduced occurrence of hepatocellular carcinoma among patients with chronic HCV infection and advanced hepatic fibrosis in our analyses could be confounded by HCV genotype or subtype. Therefore, as suggested, we have performed a multivariable Cox regression analysis adjusting for each specific HCV genotype. With this alternative model, the association between SVR and time to hepatocellular carcinoma remained similar (hazard ratio [HR], 0.16 [95% CI, 0.07-0.37]; P < .001) compared with the original model that adjusted for HCV genotype 3 vs nongenotype 3 (HR, 0.19 [95% CI, 0.08-0.44]; P < .001).


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April 10, 2013
Patrick Maisonneuve, DiplEng; Savino Bruno, MD
JAMA. 2013;309(14):1457. doi:10.1001/jama.2013.2726.
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