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Sustained Virological Response to Treatment in Patients With Chronic Hepatitis C

Patrick Maisonneuve, DiplEng; Savino Bruno, MD
JAMA. 2013;309(14):1457. doi:10.1001/jama.2013.2726.
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To the Editor: Dr van der Meer and colleagues1 demonstrated that sustained virological response (SVR) to interferon-based treatment is associated with lower all-cause mortality among patients with chronic hepatitis C virus (HCV) infection and advanced hepatic fibrosis. As a secondary aim, the authors evaluated the effect of SVR on the risk of hepatocellular carcinoma.

In a multivariable analysis after adjustment for possible confounding factors including HCV genotype (genotype 3 vs nongenotype 3; ie, pooling patients infected with HCV genotypes 1 and 2), they found a statistically significant lower rate of hepatocellular carcinoma in patients with SVR than in patients without SVR. As corroborated by the authors, only a small proportion of patients infected with genotype 1 (50 of 340; 15%) but the majority of patients infected with genotype 2 (27 of 48; 56%) achieved SVR at first treatment.


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April 10, 2013
Adriaan J. van der Meer, MD; Bettina E. Hansen, PhD; Harry L. A. Janssen, MD, PhD
JAMA. 2013;309(14):1457. doi:10.1001/jama.2013.2733.
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