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Strategies and Opportunities for Drug Development in Heart Failure

Javed Butler, MD, MPH; Gregg C. Fonarow, MD; Mihai Gheorghiade, MD
JAMA. 2013;309(15):1593-1594. doi:10.1001/jama.2013.1063.
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More than a million hospitalizations for heart failure (HHF) occur annually in the United States, with mortality and readmission rates up to 50% within 60 to 90 days after discharge. The annual costs for HF care exceed $40 billion, with the majority spent on HHF. Hospital reimbursement is now tied to 30-day readmission rates among patients with HF.1 Most HHF patients have worsening chronic HF and are receiving recommended therapies. Despite improved signs or symptoms by discharge, postdischarge event rates remain high. About half of the HHF patients have preserved left ventricular ejection fraction for which there is no evidence-based treatment.

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The American Medical Association is accredited by the Accreditation Council for Continuing Medical Education to provide continuing medical education for physicians. The AMA designates this journal-based CME activity for a maximum of 1 AMA PRA Category 1 CreditTM per course. Physicians should claim only the credit commensurate with the extent of their participation in the activity. Physicians who complete the CME course and score at least 80% correct on the quiz are eligible for AMA PRA Category 1 CreditTM.
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