Author Contributions: Dr Serisier had full access to all of the data in the study and takes responsibility for the integrity of the data and the accuracy of the data analysis.
Study concept and design: McGuckin, Bowler, Serisier.
Acquisition of data: Martin, Lourie, Chen, Brain, Biga, Schlebusch, Dash, Bowler, Serisier.
Analysis and interpretation of data: McGuckin, Schlebusch, Serisier.
Drafting of the manuscript: Serisier.
Critical revision of the manuscript for important intellectual content: All authors.
Statistical analysis: McGuckin, Serisier.
Administrative, technical, or material support: Martin, McGuckin, Lourie, Brain, Biga, Schlebusch, Dash, Bowler, Serisier.
Study supervision: McGuckin, Lourie, Schlebusch, Serisier.
Conflict of Interest Disclosures: All authors have completed and submitted the ICMJE Form for Disclosure of Potential Conflicts of Interest. Dr Serisier reported receiving honoraria for serving on the medical advisory boards of Pharmaxis, Phebra, Boehringer-Ingelheim, and GlaxoSmithKline; speaker's fees for presenting at educational meetings organized by GlaxoSmithKline, AstraZeneca, Boehringer-Ingelheim, and Pharmaxis; and travel support from Boehringer-Ingelheim to attend a scientific meeting. Dr Bowler reported receiving honoraria for serving on the medical advisory board of Novartis; speaker's fees for presenting at educational meetings organized by AstraZeneca, GlaxoSmithKline, and Boehringer-Ingelheim; and travel support from GlaxoSmithKline to attend scientific meetings. No other disclosures were reported.
Funding/Support: This study was internally funded by the Mater Adult Respiratory Research Trust Fund. No pharmaceutical company or other agency (including medical writers) had any role in this study.
Role of the Sponsor: The funding source had no role in the design and conduct of the study; in the collection, analysis, and interpretation of the data; or in the preparation, review, or approval of the manuscript.
Additional Contributions: We are extremely grateful to the efforts of those respiratory physicians from other centers who referred patients directly for involvement in this study, including Khoa Tran, MBBS, Logan Hospital, Meadowbrook, Australia; Josie Stroud, MBBS, Logan Hospital, Meadowbrook, Australia; Luke Garske, MBBS, Princess Alexandra Hospital, Woolloongabba, Australia; Bill Oliver, MBBS, The Prince Charles Hospital, Chermside, Australia; Sam Kim, MBBS, St Andrews Hospital, Spring Hill, Australia; John Upham, PhD, Princess Alexandra Hospital, Woolloongabba, Australia, and Wayne Kelly, MBBS, Brisbane Private Hospital, Brisbane, Australia. We thank Rebecca Keating, MN (Mater Adult Hospital, South Brisbane, Australia), for assistance with patient procedures and Mervyn R. Thomas, DPhil (Emphron Informatics, Toowong, Australia), for statistical support. We are also grateful for additional statistical support provided by Jinlin Fu, PhD. None of the acknowledged contributors received financial recompense for their involvement. We are indebted to the participants who willingly gave their time and enthusiasm to be involved in this study.