AuthorContributions: Dr Clair had full access to all of the data in the study and takes responsibility for the integrity of the data and the accuracy of the data analysis.
Study concept and design: Clair, Rigotti, Meigs.
Acquisition of data: Porneala, Fox, D’Agostino, Meigs.
Analysis and interpretation of data: Clair, Rigotti, Porneala, D’Agostino, Pencina, Meigs.
Drafting of the manuscript: Clair.
Critical revision of the manuscript for important intellectual content: Clair, Rigotti, Porneala, Fox, D’Agostino, Pencina, Meigs.
Statistical analysis: Clair, Porneala, D’Agostino, Meigs.
Obtained funding: D’Agostino, Meigs.
Administrative, technical, or material support: Meigs.
Study supervision: Clair, Rigotti, Fox, Meigs.
Conflict of Interest Disclosures: All authors have completed and submitted the ICMJE Form for Disclosure of Potential Conflicts of Interest. Dr Rigotti reported serving as an unpaid consultant to Pfizer and Allere Wellbeing Inc; conducting research projects sponsored by Pfizer and Nabi Biopharmaceuticals; and receiving royalties from UpToDate Inc for chapters related to smoking cessation. Dr Pencina reported serving as a data and safety monitoring board member for Thoracos. No other authors reported disclosures.
Funding/Support: Dr Clair was supported by a grant from the Swiss National Science Foundation (PBLAP3-127728/1) and by a grant from the SICPA Foundation. Dr Rigotti was supported by National Heart, Lung, and Blood Institute (NHLBI) grant 5K24HL4440-10. Dr Meigs was supported by National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK) grant K24 DK080140.
Role of the Sponsors: The Swiss National Science Foundation, SICPA Foundation, and NIDDK had no role in the design and conduct of the study; the collection, management, analysis, and interpretation of the data; or the preparation, review, or approval of the manuscript. The Framingham Heart Study is supported by the NHLBI Framingham Heart Study (contract N01-HC-25195 [Drs D’Agostino and Pencina]). The NHLBI approved the manuscript.
Previous Presentations: Parts of the data of this manuscript were presented as an oral presentation at the 34th annual meeting of the Society of General Internal Medicine in May 2011.
Online-Only Material: Author Video Interview is available here.
Additional Contributions: Peter Shrader, MS (General Medicine Division, Massachusetts General Hospital, Boston), contributed to the statistical analyses. He was compensated for his work.