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Genetic Variants Modifying the Influence of Vitamin D

Adrian R. Martineau, MRCP, PhD; David A. Jolliffe, BSc
JAMA. 2013;309(9):872-873. doi:10.1001/jama.2013.635.
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To the Editor: Dr Levin and colleagues1 adopted a novel systematic approach to identify genetic variants modifying the influence of vitamin D on human health. Their findings have significance for the analysis and interpretation of the burgeoning number of clinical trials of vitamin D supplementation currently being undertaken worldwide. By way of validation, the variant in the VDR gene identified as modifying effects in their study (rs7968585) was found to be in linkage disequilibrium with another VDR variant (rs731236) that modified the effect of vitamin D supplementation on response to tuberculosis therapy.2 However, we wonder whether some aspects of their study design may have led to other potentially important effect-modifying variants being missed.

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March 6, 2013
Gregory P. Levin, PhD; Bryan Kestenbaum, MD, MS
JAMA. 2013;309(9):872-873. doi:10.1001/jama.2013.638.
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