Health Agencies Update |

Herbal Medicine Examined

Bridget M. Kuehn, MSJ
JAMA. 2013;309(8):759. doi:10.1001/jama.2013.854.
Text Size: A A A
Published online


Febrifugine, a traditional Chinese medicine used to treat fever associated with malaria, likely inhibits the synthesis of proteins in humans and the Plasmodium falciparum parasite. This property may explain the compound's mechanism of action, according to a study funded by the National Institute of General Medical Sciences that investigated the compound's structure and interactions.

Febrifugine is the active ingredient in Chang Shan, an herbal remedy believed to have been used for about 2000 years, according to the study's authors (Zhou H et al. Nature. 2013;494[7435]:121-124). Previous evidence suggests that halofuginone, which is derived from febrifugine, suppresses the immune system; this derivative has been tested in clinical trials as a treatment for cancer and scleroderma. The new study probed the precise chemical structure of halofuginone and how it interacts with other compounds.

Figures in this Article

Sign In to Access Full Content

Don't have Access?

Register and get free email Table of Contents alerts, saved searches, PowerPoint downloads, CME quizzes, and more

Subscribe for full-text access to content from 1998 forward and a host of useful features

Activate your current subscription (AMA members and current subscribers)

Purchase Online Access to this article for 24 hours

First Page Preview

View Large
First page PDF preview


Place holder to copy figure label and caption

Graphic Jump LocationImage not available.

A Chinese herbal remedy derived from a type of hydrangea and used for fever associated with malaria inhibits protein synthesis in the malaria parasite, a new study suggests.

(Photo credit: Photo credit: Keith Edkins)



Meets CME requirements for:
Browse CME for all U.S. States
Accreditation Information
The American Medical Association is accredited by the Accreditation Council for Continuing Medical Education to provide continuing medical education for physicians. The AMA designates this journal-based CME activity for a maximum of 1 AMA PRA Category 1 CreditTM per course. Physicians should claim only the credit commensurate with the extent of their participation in the activity. Physicians who complete the CME course and score at least 80% correct on the quiz are eligible for AMA PRA Category 1 CreditTM.
Note: You must get at least of the answers correct to pass this quiz.
You have not filled in all the answers to complete this quiz
The following questions were not answered:
Sorry, you have unsuccessfully completed this CME quiz with a score of
The following questions were not answered correctly:
Commitment to Change (optional):
Indicate what change(s) you will implement in your practice, if any, based on this CME course.
Your quiz results:
The filled radio buttons indicate your responses. The preferred responses are highlighted
For CME Course: A Proposed Model for Initial Assessment and Management of Acute Heart Failure Syndromes
Indicate what changes(s) you will implement in your practice, if any, based on this CME course.
Citing articles are presented as examples only. In non-demo SCM6 implementation, integration with CrossRef’s "Cited By" API will populate this tab (http://www.crossref.org/citedby.html).


Some tools below are only available to our subscribers or users with an online account.

Sign In to Access Full Content

Related Content

Customize your page view by dragging & repositioning the boxes below.

Articles Related By Topic
Related Topics
PubMed Articles