In Reply: Drs Patel and Josephson raise 3 important issues in relation to the generalizability of our results beyond the 6 Canadian sites participating in the ARIPI trial: (1) the interaction between storage age and transfusion thresholds, (2) differences in outcomes related to RBC production methods, and (3) the average age of storage duration in the control group.
The potential interaction between transfusion thresholds and storage age is intriguing and deserves further inquiry. We purposely chose a standard care group in the ARIPI trial to reflect current local transfusion and blood bank practice. As such, there was some variability in transfusion threshold practice between sites and a post hoc analysis did not identify appreciable differences in our primary outcome from the more conservative sites compared with the more liberal sites (unadjusted range of mean pretransfusion episode hemoglobin: 8.7-10.7 g/dL).
Some tools below are only available to our subscribers or users with an online account.
Download citation file:
Web of Science® Times Cited: 1
Customize your page view by dragging & repositioning the boxes below.
More Listings atJAMACareerCenter.com >
Enter your username and email address. We'll send you a link to reset your password.
Enter your username and email address. We'll send instructions on how to reset your password to the email address we have on record.
Athens and Shibboleth are access management services that provide single sign-on to protected resources. They replace the multiple user names and passwords necessary to access subscription-based content with a single user name and password that can be entered once per session. It operates independently of a user's location or IP address. If your institution uses Athens or Shibboleth authentication, please contact your site administrator to receive your user name and password.