In Reply: Dr Albert is concerned that the renal changes we observed could be explained by differences in sodium administration. He highlights the apparent discrepancy between the sodium received by the entire cohort vs the nested cohort. However, the sodium received by the entire cohort was the mean value, whereas the median value was presented for the nested cohort. In these 100 patients, the mean amount of sodium received per patient during the control period was 473 mmol (95% CI, 366-580 mmol) compared with 433 mmol (95% CI, 351-515 mmol) during the intervention period (P = .55); the respective values for the whole cohort were 750 mmol and 623 mmol.
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