Editorial |

Antibiotics for Skin Infections:  New Study Design and a Step Toward Shorter Course Therapy

Shira Doron, MD; Helen W. Boucher, MD
JAMA. 2013;309(6):609-611. doi:10.1001/jama.2013.604.
Text Size: A A A
Published online


In this issue of JAMA, Prokocimer et al1 present the results of ESTABLISH-1 (Efficacy and Safety of 6-day Oral Tedizolid in Acute Bacterial Skin and Skin Structure Infections vs 10-day Oral Linezolid Therapy), an international, multicenter, double-blind, phase 3, noninferiority trial comparing a 6-day course of oral tedizolid phosphate once daily with a 10-day course of oral linezolid twice daily for treatment of acute bacterial skin and skin structure infections (ABSSSIs). Among 667 adults with ABSSSIs randomized to treatment with tedizolid phosphate (n = 332) or linezolid (n = 335), the early clinical treatment response rates were 79.5% with tedizolid phosphate and 79.4% with linezolid, a treatment difference of 0.1% (95% CI, −6.1% to 6.2%). The sustained clinical treatment response rates at the end of treatment (day 11) were 69.3% with tedizolid phosphate and 71.9% with linezolid (a treatment difference of −2.6% [95% CI, −9.6% to 4.2%]), with the lower bounds of the 95% confidence intervals within the prespecified 10% noninferiority margin. The authors concluded that tedizolid phosphate was statistically noninferior to linezolid in achieving early clinical response after initiating therapy for ABSSSI.

Sign In to Access Full Content

Don't have Access?

Register and get free email Table of Contents alerts, saved searches, PowerPoint downloads, CME quizzes, and more

Subscribe for full-text access to content from 1998 forward and a host of useful features

Activate your current subscription (AMA members and current subscribers)

Purchase Online Access to this article for 24 hours

First Page Preview

View Large
First page PDF preview




Meets CME requirements for:
Browse CME for all U.S. States
Accreditation Information
The American Medical Association is accredited by the Accreditation Council for Continuing Medical Education to provide continuing medical education for physicians. The AMA designates this journal-based CME activity for a maximum of 1 AMA PRA Category 1 CreditTM per course. Physicians should claim only the credit commensurate with the extent of their participation in the activity. Physicians who complete the CME course and score at least 80% correct on the quiz are eligible for AMA PRA Category 1 CreditTM.
Note: You must get at least of the answers correct to pass this quiz.
You have not filled in all the answers to complete this quiz
The following questions were not answered:
Sorry, you have unsuccessfully completed this CME quiz with a score of
The following questions were not answered correctly:
Commitment to Change (optional):
Indicate what change(s) you will implement in your practice, if any, based on this CME course.
Your quiz results:
The filled radio buttons indicate your responses. The preferred responses are highlighted
For CME Course: A Proposed Model for Initial Assessment and Management of Acute Heart Failure Syndromes
Indicate what changes(s) you will implement in your practice, if any, based on this CME course.
Citing articles are presented as examples only. In non-demo SCM6 implementation, integration with CrossRef’s "Cited By" API will populate this tab (http://www.crossref.org/citedby.html).


Some tools below are only available to our subscribers or users with an online account.

Sign In to Access Full Content

Related Content

Customize your page view by dragging & repositioning the boxes below.

Articles Related By Topic
Related Topics
PubMed Articles

Users' Guides to the Medical Literature
Clinical Resolution

Users' Guides to the Medical Literature
Clinical Scenario