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β-Blocker Use for Patients With or at Risk for Coronary Artery Disease—Reply

Sripal Bangalore, MD, MHA; P. Gabriel Steg, MD; Deepak L. Bhatt, MD, MPH
JAMA. 2013;309(5):438. doi:10.1001/jama.2012.128872.
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In Reply: Dr Shang contends that our results are mostly confirmation of a well-known fact that atenolol is ineffective and may not be generalized to other β-blockers such as carvedilol. This statement highlights the discordance between trials and practice and an optimism bias based on perceived benefit of a newer agent assessed by surrogate end points only.

The well-known fact that atenolol is ineffective has not translated into clinical practice—atenolol was the second top generic drug based on retail dollars in 2010.1 The data on β-blocker use in patients without heart failure are based on older agents and as a result, there is no guideline recommendation of a preferred β-blocker.


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February 6, 2013
Charles Shang, MD
JAMA. 2013;309(5):438. doi:10.1001/jama.2012.128869.
February 6, 2013
Frans H. Rutten, MD, PhD; Rolf H. H. Groenwold, MD, PhD
JAMA. 2013;309(5):438. doi:10.1001/jama.2012.128865.
February 6, 2013
Dominique Costagliola, PhD; Miguel A. Hernán, MD, PhD
JAMA. 2013;309(5):438. doi:10.1001/jama.2012.128862.
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