0
We're unable to sign you in at this time. Please try again in a few minutes.
Retry
We were able to sign you in, but your subscription(s) could not be found. Please try again in a few minutes.
Retry
There may be a problem with your account. Please contact the AMA Service Center to resolve this issue.
Contact the AMA Service Center:
Telephone: 1 (800) 262-2350 or 1 (312) 670-7827  *   Email: subscriptions@jamanetwork.com
Error Message ......
Lab Reports |

Restoring the Blood-Brain Barrier

Tracy Hampton, PhD
JAMA. 2013;309(5):431. doi:10.1001/jama.2013.267.
Text Size: A A A
Published online

Extract

Mice lacking an anti-inflammatory protein called annexin A1 (ANXA1) exhibit significant decreases in the integrity of the blood-brain barrier, reports a team led by researchers at the Queen Mary, University of London, in England (Cristante E et al. Proc Natl Acad Sci U S A. doi:10.1073/pnas.1209362110 [published online December 31, 2012]).

The investigators also found a significant reduction in circulating ANXA1 in the plasma of patients with multiple sclerosis and a loss of the protein in the cerebral microvasculature of patients who died with the disease. Exposing in vitro cerebrovascular endothelial cells to recombinant ANXA1 restored cellular features (such as cytoskeleton integrity) needed to reinstate the integrity of the blood-brain barrier. Also, giving ANXA1 to mice that lacked the protein decreased leakage through the blood-brain barrier.

Sign in

Create a free personal account to sign up for alerts, share articles, and more.

Purchase Options

• Buy this article
• Subscribe to the journal

First Page Preview

View Large
First page PDF preview

First Page Preview

View Large
First page PDF preview

Figures

Tables

References

CME
Also Meets CME requirements for:
Browse CME for all U.S. States
Accreditation Information
The American Medical Association is accredited by the Accreditation Council for Continuing Medical Education to provide continuing medical education for physicians. The AMA designates this journal-based CME activity for a maximum of 1 AMA PRA Category 1 CreditTM per course. Physicians should claim only the credit commensurate with the extent of their participation in the activity. Physicians who complete the CME course and score at least 80% correct on the quiz are eligible for AMA PRA Category 1 CreditTM.
Note: You must get at least of the answers correct to pass this quiz.
Your answers have been saved for later.
You have not filled in all the answers to complete this quiz
The following questions were not answered:
Sorry, you have unsuccessfully completed this CME quiz with a score of
The following questions were not answered correctly:
Commitment to Change (optional):
Indicate what change(s) you will implement in your practice, if any, based on this CME course.
Your quiz results:
The filled radio buttons indicate your responses. The preferred responses are highlighted
For CME Course: A Proposed Model for Initial Assessment and Management of Acute Heart Failure Syndromes
Indicate what changes(s) you will implement in your practice, if any, based on this CME course.

Multimedia

Some tools below are only available to our subscribers or users with an online account.

Sign in

Create a free personal account to sign up for alerts, share articles, and more.

Purchase Options

• Buy this article
• Subscribe to the journal

Related Content

Customize your page view by dragging & repositioning the boxes below.

Related Collections
PubMed Articles
Jobs
brightcove.createExperiences();